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Updated: Jan 29, 2026
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A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
Published on: June 15, 2011
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[Association between the Thalamus and Social Function in Schizophrenia]
Daisuke Koshiyama1, Kiyoto Kasai
1Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo.
Brain and Nerve = Shinkei Kenkyu No Shinpo
|February 6, 2019
Summary
Schizophrenia patients
Area of Science:
- Neuroscience
- Psychiatry
- Radiology
Background:
- Schizophrenia impairs social cognition, impacting daily life.
- The exact neural underpinnings of this social dysfunction remain unclear.
Purpose of the Study:
- To investigate the thalamus's role in schizophrenia-related social dysfunction.
- To identify specific neural correlates of impaired social function in schizophrenia.
Main Methods:
- Utilized T1-weighted magnetic resonance imaging (MRI) for volumetric analysis.
- Employed diffusion tensor imaging (DTI) to assess white matter integrity.
- Focused on the thalamus and its connections to the frontal lobe.
Main Results:
- Reduced right thalamic volume correlated with social function deficits.
- Decreased white matter integrity between the right thalamus and frontal lobe was observed.
- These structural and connectivity differences are linked to social cognition impairment.
Conclusions:
- Neural network abnormalities between the thalamus and frontal lobe are associated with social dysfunction in schizophrenia.
- Findings suggest potential therapeutic targets for improving social function in schizophrenia patients.
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