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Updated: Jan 29, 2026

A Multiple Integrated Social Stress Model for Psychiatric Disorders in Female C57BL/6J Mice
Published on: July 15, 2025
The genomics of major psychiatric disorders in a large pedigree from Northern Sweden
Jin Szatkiewicz1, James J Crowley1, Annelie Nordin Adolfsson2
1Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Abstract:
We searched for genetic causes of major psychiatric disorders (bipolar disorder, schizoaffective disorder, and schizophrenia) in a large, densely affected pedigree from Northern Sweden that originated with three pairs of founders born around 1650. We applied a systematic genomic approach to the pedigree via karyotyping (N = 9), genome-wide SNP arrays (N = 418), whole-exome sequencing (N = 26), and whole-genome sequencing (N = 10). Comprehensive analysis did not identify plausible variants of strong effect. Rather, pedigree cases had significantly higher genetic risk scores compared to pedigree and community controls.
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