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Morphological changes in the CNS after Dimer X ventriculography.

M Kun, J Alwasiak, J Grońska

    Neuroradiology
    |April 27, 1978
    PubMed
    Summary
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    Dimer X injection into the brain's ventricular system caused morphological changes in cats and human patients. These lesions, including inflammation, were most severe within two days but some persisted for 30 days.

    Area of Science:

    • Neuroscience
    • Pathology
    • Radiology

    Background:

    • Dimer X is a contrast agent used in ventriculography.
    • Understanding the potential neuropathological effects of Dimer X is crucial for patient safety.

    Purpose of the Study:

    • To investigate the morphological changes in the brain following stereotactic injection of Dimer X.
    • To evaluate the temporal progression and persistence of these changes.

    Main Methods:

    • Stereotactic injection of Dimer X into the ventricular system of 89 cats.
    • Histopathological examination of brain tissue at various time points (6h, 24h, 48h, 7 days, 30 days).
    • Comparison with postmortem brain samples from 20 human patients who underwent Dimer X ventriculography.

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    Main Results:

    • Morphological alterations observed in the ependyma, choroid plexuses, subependymal zone, and brain tissue.
    • Lesions were most intense within the first 2 days post-injection.
    • Persistent lesions, including subependymal inflammatory infiltrates and ependymitis granularis, were noted up to 30 days.
    • Similar pathological changes were found in human patients.

    Conclusions:

    • Stereotactic injection of Dimer X can induce significant neuropathological changes.
    • These changes exhibit a temporal pattern, with early intense effects and some long-term persistence.
    • Findings highlight potential risks associated with Dimer X use in neuroimaging procedures.