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Elevated Serum S100A9 Indicated Poor Prognosis in Hepatocellular Carcinoma after Curative Resection
Jun Meng1, Feng Gu2, Hua Fang2
1Department of Clinical Laboratory, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197, Rui Jin Er Road, Shanghai 200025, P.R. China.
Insights
Serum S100A9 is a valuable prognostic biomarker for hepatocellular carcinoma (HCC) patients post-resection. Elevated S100A9 levels indicate a higher risk of recurrence and poorer survival, aiding in personalized treatment strategies.
Area of Science:
- Oncology
- Biomarker Discovery
- Hepatocellular Carcinoma Research
Background:
- S100A9 has shown potential as a prognostic biomarker in various cancers, including HCC.
- Previous research indicates its promise, necessitating further investigation into its specific role in HCC prognosis post-curative resection.
Purpose of the Study:
- To evaluate the prognostic utility of serum S100A9 levels in predicting outcomes for hepatocellular carcinoma patients following curative resection.
- To determine if S100A9 can serve as an independent indicator of prognosis in this patient cohort.
Main Methods:
- A retrospective study involving 379 HCC patients who underwent curative resection.
- Serum S100A9 levels were measured using ELISA and patients were stratified into training and validation cohorts.
- Prognostic value was assessed using survival analysis and Cox regression.
Main Results:
- Significantly higher S100A9 levels were observed in patients with advanced disease and those who experienced recurrence or death.
- Higher preoperative S100A9 correlated with shorter recurrence-free survival and overall survival in the training cohort.
- S100A9 was identified as an independent predictor of poor prognosis, with findings validated in a separate cohort.
Conclusions:
- Serum S100A9 is significantly associated with adverse outcomes in HCC patients after resection.
- S100A9 can function as a novel and independent prognostic biomarker for hepatocellular carcinoma.
- Measuring S100A9 may assist in tailoring treatment plans to improve patient prognosis.
Abstract:
Background: Previous studies suggest S100A9 is a promising biomarker for prognosis in cancer, including hepatocellular carcinoma (HCC). We examined the utility of serum S100A9 in predicting prognosis in HCC after curative resection. Methods: We conducted a retrospective study of 379 HCC patients who underwent curative resection. Patients were randomly stratified into two independent groups to evaluate the prognostic value of S100A9. S100A9 was determined by ELISA. Results: Patients with advanced disease showed significantly higher S100A9 levels (all P < 0.050). Serum S100A9 was elevated in patients who developed recurrence and death in both training and validation cohorts (all P < 0.050). In the training cohort, patients with higher preoperative S100A9 had a significantly shorter time to recurrence (15.50 vs. 64.00 months, P < 0.001) and decreased overall survival (34.80 months vs. not reached, P < 0.001). Cox regression demonstrated S100A9 was an independent indicator for poor prognosis after resection (both P < 0.050). These results were confirmed by the independent validation cohort. Conclusions: Serum S100A9 is associated with dismal outcomes in HCC patients and can serve as a novel prognostic indicator for HCC patients after resection. Determination of S100A9 might help tailor treatment strategy to improve HCC patient prognosis.
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