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Updated: Jan 29, 2026

Guided Protocol for Fecal Microbial Characterization by 16S rRNA-Amplicon Sequencing
Published on: March 19, 2018
Implications of sequence variation on the evolution of rRNA
Matthew M Parks1, Chad M Kurylo1, Jake E Batchelder2
1Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
Abstract:
The evolution of the multi-copy family of ribosomal RNA (rRNA) genes is unique in regard to its genetics and genome evolution. Paradoxically, rRNA genes are highly homogenized within and between individuals, yet they are globally distinct between species. Here, we discuss the implications for models of rRNA gene evolution in light of our recent discoveries that ribosomes bearing rRNA sequence variants can affect gene expression and physiology and that intra-individual rRNA alleles exhibit both context- and tissue-specific expression.
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