Related Experiment Video
Updated: Jan 29, 2026

Author Spotlight: Insights and Innovations in Gene Expression Manipulation Techniques for Choroid Plexus Research
Published on: June 16, 2023
Direct and crossover effects of brinzolamide, betaxolol, and latanoprost on choroidal thickness
Murat Okutucu1, Hüseyin Fındık1, Mehmet Gökhan Arslan1
1a Department of Opthalmology , Recep Tayyip Erdoğan Üniversitesi Zihni Derin Yerleşkesi , Rize , Turkey.
Purpose:
To investigate the acute effects of brinzolamide, betaxolol, and latanoprost (drugs commonly used in the medical management of glaucoma) on choroidal thickness using enhanced depth imaging optical coherence tomography (EDI-OCT).
Methods:
Ninety healthy volunteers were evaluated in this prospective study. Participants were randomly divided into 3 groups. Brinzolamide, betaxolol, and latanoprost were administered into the left eyes of the first group (n = 30), second group (n = 30), and third group (n = 30), respectively, and artificial tear (Sodium hyaluronate) was instilled into the right eyes of all participants. Subfoveal choroidal thickness (SFCT) was measured using EDI-OCT before and 45 minutes after administration of the antiglaucomatous drops.
Results:
SFCT revealed a significant increase in the left eye (administered antiglaucomatous drop) in the brinzolamide (p = 0.001) and betaxolol groups (p = 0.049) and a significant increase also in the right eye (administered artificial drop) in the brinzolamide (p = 0.001) and betaxolol groups (p = 0.001). However, SFCT did not reveal a significant increase in the left eye (p = 0.213) or in the right eye (p = 0.062) in the latanoprost group.
Conclusion:
Brinzolamide and betaxolol caused an increase in SFCT, while latanoprost had no significant effect on SFCT.
Related Concept Videos
Crossover Experiments
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.
Directing and Steric Effects in Disubstituted Benzene Derivatives
Design Example: Deciding Thickness of Lubricating Fluid in a Shaft
To calculate the required thickness of the lubricant layer, the tangential velocity at the shaft's surface must first be determined. This velocity is calculated by converting the rotational speed to angular velocity...
Directing Effect of Substituents: meta-Directing Groups
Buffer Effectiveness
The buffer capacity is the amount of acid or base that can be added to a given volume...
Framing Effects

