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Myopathies associated with hypothyroidism: a review based upon 13 cases
F L Mastaglia1, V J Ojeda, H B Sarnat
1University of Western Australia, Queen Elizabeth II Medical Centre, WA.
Australian and New Zealand Journal of Medicine
|October 1, 1988
Summary
Hypothyroidism can cause various muscle disorders, including hypothyroid myopathy and inflammatory myopathies. Treatment with thyroxine normalized creatine kinase levels in hypothyroid myopathy patients.
Area of Science:
- Neurology
- Endocrinology
- Pathology
Background:
- Hypothyroidism is associated with diverse neuromuscular complications.
- Understanding the spectrum of myopathies in hypothyroid patients is crucial for diagnosis and management.
Observation:
- This study presents 13 patients with myopathy associated with hypothyroidism.
- Seven patients exhibited hypothyroid myopathy (including Hoffmann and Kocher-Debre-Semelaigne syndromes).
- Other diagnoses included inflammatory myopathy and polymyalgia rheumatica.
Findings:
- Elevated serum creatine kinase (CK) levels (up to 12-fold) were observed in hypothyroid myopathy.
- CK levels normalized after thyroxine treatment.
- Histopathological findings varied, including fiber atrophy/hypertrophy, necrosis, regeneration, and core-like areas.
Implications:
- Hypothyroid myopathy presents with significant clinical and histopathological heterogeneity.
- Consideration of other myopathies is essential in hypothyroid patients with muscular symptoms.
- Early diagnosis and treatment of hypothyroidism can improve myopathic outcomes.