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Pulmonary Nodular Lymphoid Hyperplasia
Maggie Yell1, Flavia G Rosado1
1From the Department of Pathology, Anatomy and Laboratory Medicine, West Virginia University, Morgantown (Dr Yell); and the Department of Pathology, University of Texas Southwestern Biocenter, Dallas (Dr Rosado).
Abstract:
Pulmonary nodular lymphoid hyperplasia is an uncommon reactive lymphoproliferative disorder that presents as an asymptomatic lung mass. The histopathologic diagnosis of pulmonary nodular lymphoid hyperplasia may be challenging because of its morphologic overlap with other diseases, such as extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue and immunoglobulin G4-related sclerosing disease. Despite the similarities, there are distinctive morphologic and phenotypic features that allow for the correct diagnosis in the majority of cases. This review aims to discuss the clinicopathologic features of pulmonary nodular lymphoid hyperplasia and contrast them with its histopathologic mimickers.
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