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Updated: Jan 29, 2026

A Technique to Functionalize and Self-assemble Macroscopic Nanoparticle-ligand Monolayer Films onto Template-free Substrates
Published on: May 9, 2014
Facile Buchwald-Hartwig coupling of sterically encumbered substrates effected by PNP ligands
Neha Kathewad1, Anagha M C, Nasrina Parvin
1Department of Chemistry, Indian Institute of Science Education and Research Pune, Dr. Homi Bhabha Road, Pashan, Pune-411008, India. shabana@iiserpune.ac.in.
Abstract:
The diphosphinoamine ligands [(Ph2P)2N(Ar); 1 (Ar = C6H5), 2 (Ar = 2,6-iPr2C6H3)] were effectively utilized in Buchwald-Hartwig coupling of a range of sterically demanding substrates. The reaction was carried out using conventional and microwave routes and the latter reduces the reaction time from 3 d to 15-30 min. A broad substrate scope was achieved in this protocol and most of the coupling products are isolated on a mutligram scale. DFT calculations were carried out to elucidate the reaction mechanism.
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