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Bead Based Multiplex Assay for Analysis of Tear Cytokine Profiles
Published on: October 13, 2017
[Study of cytokine profile in men with hypertension.]
I I Chukaeva1, L V Gankovskaya1, N V Orlova1
1Pirogov Russian National Research Medical university, 117997, Moscow, Russia.
Insights
Inflammation plays a key role in hypertension development in men. Inflammatory biomarkers correlate with cardiovascular risk factors like obesity and dyslipidemia, impacting target organ damage.
Area of Science:
- Cardiovascular Medicine
- Inflammation Research
- Metabolic Syndrome
Background:
- Gender disparities exist in cardiovascular disease (CVD) risk factors.
- Inflammation is a critical mechanism linking risk factors to hypertension.
- Understanding these links in men is crucial for targeted interventions.
Purpose of the Study:
- To investigate the relationship between inflammatory biomarkers and hypertension in men.
- To explore the association between these biomarkers and cardiovascular risk factors (obesity, dyslipidemia, hyperglycemia).
- To determine the impact of inflammation on target organ damage in hypertensive men.
Main Methods:
- Study included 60 hypertensive men (low vs. high cardiovascular risk) and 86 hypertensive patients with risk factors.
- Assessed a panel of cytokines (IL-4, IL-8, IL-10, IL-12, IL-17, IL-18, TGF-β, TNF-α, IFN-γ), HS-CRP, and fibrinogen.
- Correlated biomarker levels with echocardiography (EchoCG), ambulatory blood pressure monitoring (ABPM), carotid artery duplex scanning, BMI, and metabolic parameters.
Main Results:
- Direct correlation found between risk factors and target organ damage (left ventricular hypertrophy, increased intima-media thickness).
- Cytokine profiles varied significantly based on cardiovascular risk, obesity, hyperglycemia, and dyslipidemia.
- Inflammation showed a stronger association with lipid metabolism than other risk factors in hypertensive men.
Conclusions:
- Inflammatory biomarkers are significantly associated with hypertension and cardiovascular risk factors in men.
- The severity of inflammation correlates with obesity, dyslipidemia, hyperglycemia, and hypertension duration.
- These findings highlight inflammation's central role in hypertension pathogenesis and target organ damage in men.
Abstract:
Gender differences in the risk factors' influence on the development of cardiovascular diseases determine the study of the pathogenetic causes of these features. Inflammatory is one of the mechanisms for the participation of risk factors in the development of hypertension. The aim of the study was to investigate the relationship between inflammatory biomarkers with hypertension and cardiovascular risk factors in men. The study included 60 men with hypertension who were divided into groups depending on the risk of cardiovascular events: 30 men with low risk and 30 men with high risk. 86 hypertensive patients with risk factors such as obesity, impaired glucose metabolism, impaired lipid metabolism also were examined. Biochemical parameters and a wide range of cytokines: IL-4, IL - 8, IL-10, IL-12, IL-17, IL-18, TGF-β, TNF-α, IFN-γ were estimated. The obtained results were compared with echocardiographic (EchoCG), ambulatory blood pressure monitoring (ABPM), duplex scanning of the carotid arteries. A direct correlation between the risk factors and target organs' damage - left ventricular hypertrophy, increased intima-media complex thickness, was revealed. The dependence of cytokine profile from risk of cardiovascular events in men was also revealed. We studied the contribution of individual risk factors in men in the development of hypertension and the severity of inflammation. More significant changes in the cytokine profile observed in patients with concomitant hyperglycemia, obesity and dyslipidemia. A correlation between cytokine profile and duration of hypertension also revealed. Correlation analysis revealed the relationship between ABPM parameters and levels of interleukins, HS-CRP, and fibrinogen. Biomarkers of inflammation associated with the severity of visceral obesity, with a BMI. Analysis of results also showed the relationship between hyperinsulinemia or insulin resistance and inflammatory biomarkers. The relationship of inflammation with lipid metabolism in hypertensive men was more significant than with the other studied risk factors.
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