[(EXPERIENCE WITH ALBENDAZOLE TREATMENT IN CHILDREN WITH CYSTIC ECHINOCOCCOSIS)]
Meditsinskaia Parazitologiia I Parazitarnye Bolezni
|February 6, 2019
Summary
Albendazole chemotherapy is effective for treating cystic echinococcosis, particularly in children, by preventing recurrence and reducing cyst size. However, hepatotoxicity is a notable side effect of this treatment.
Area of Science:
- Medical Parasitology
- Pharmacology
Background:
- Cystic echinococcosis is a parasitic infection caused by Echinococcus granulosus.
- Treatment options for cystic echinococcosis can be limited, necessitating evaluation of chemotherapeutic agents.
Purpose of the Study:
- To analyze the tolerability and efficiency of albendazole chemotherapy in patients with cystic echinococcosis.
- To assess the effectiveness of albendazole in preventing recurrence and reducing cyst burden.
Main Methods:
- Retrospective analysis of 18 patients with cystic echinococcosis.
- Evaluation of albendazole treatment cycles and observed outcomes.
- Monitoring for adverse effects, specifically hepatotoxicity.
Main Results:
- Albendazole demonstrated effectiveness in reducing the number and size of small hydatid cysts in the liver and lungs after 4-5 treatment cycles.
- Albendazole chemotherapy, especially over at least 3 cycles, was highly effective in preventing recurrent echinococcosis in pediatric patients.
- Hepatotoxicity was identified as the most common complication associated with albendazole treatment.
Conclusions:
- Albendazole is an effective chemotherapeutic agent for managing cystic echinococcosis.
- Long-term albendazole treatment can prevent disease recurrence in children.
- Close monitoring for hepatotoxicity is crucial during albendazole therapy.
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