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Seizure outcome and epilepsy patterns in patients with cerebral palsy

Noha T El Tantawi1, Dina S Abd Elmegid1, Eman Atef1

  • 1Neurology Unit, Paediatrics Department, Mansoura University Children Hospital, Mansoura, Egypt.

Seizure
|February 6, 2019
PubMed

Insights

Epilepsy remission in cerebral palsy (CP) patients is achievable for 45% but requires long treatment. Factors like CP type and seizure types influence outcomes in pediatric epilepsy.

Area of Science:

  • Neurology
  • Pediatric Epilepsy
  • Cerebral Palsy Research

Background:

  • Epilepsy is a common comorbidity in children with cerebral palsy (CP).
  • Understanding epilepsy patterns and remission factors in CP is crucial for effective management.

Purpose of the Study:

  • To investigate epilepsy patterns and outcomes in pediatric patients with cerebral palsy (CP).
  • To identify variables that predict seizure remission in this population.

Main Methods:

  • Retrospective cohort study of 107 CP patients (aged 1-16) with newly diagnosed epilepsy.
  • Categorization of patients based on 4 epilepsy patterns and seizure freedom over 2 years.
  • Analysis of prognostic variables for remission, including CP type, mobility, and seizure types.

Main Results:

  • 45% of CP patients achieved seizure remission after extended treatment.
  • Epilepsy patterns observed: sustained freedom (6.5%), delayed freedom (27.1%), relapsing-remitting (43.9%), and never attained (22.4%).
  • CP type, mobility, and number of seizure types significantly impacted remission rates.

Conclusions:

  • Achieving epilepsy remission in CP patients is possible but often requires prolonged treatment.
  • Patient- and epilepsy-related factors are key determinants of remission.
  • Further research is needed to fully elucidate these influencing factors.
Abstract

Keywords:
Cerebral palsyEpilepsyOutcomePatterns

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