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Multimodal Parcellations and Extensive Behavioral Profiling Tackling the Hippocampus Gradient.

Anna Plachti^1,2, Simon B Eickhoff^1,2, Felix Hoffstaedter^1,2

¹Institute of Systems Neuroscience, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

Cerebral Cortex (New York, N.Y. : 1991)

|February 6, 2019

Summary

This study integrates multiple brain imaging techniques to map the hippocampus, revealing distinct functional and structural organization critical for memory and navigation. These findings provide a detailed functional map of the hippocampus for future research.

Keywords:

anterior–posterior gradient map medial temporal lobe structural covariance

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Area of Science:

Neuroscience
Neuroimaging
Brain Anatomy

Background:

The hippocampus has a complex organization, with its subfield arrangement differing between anatomical and functional dimensions.
Neuropathologies often perturb hippocampal function, highlighting the need for detailed mapping.

Purpose of the Study:

To integrate multimodal data for a comprehensive view of hippocampal structural and functional differentiation.
To develop robust, openly available functional maps of the hippocampus.

Main Methods:

Applied connectivity-based parcellation using intrinsic connectivity, task-based connectivity, and structural covariance.
Defined functional maps based on consistent functional parcellations across different partition levels.

Main Results:

Functional parcellations (intrinsic and task-based) showed a primary anterior-posterior organization.
Structural covariance revealed a hybrid pattern, reflecting both functional and cytoarchitectonic subdivisions.
Developed functional maps detailing head-body and tail partitions along anterior-posterior and medial-lateral axes.

Conclusions:

Functional maps reveal an anterior-posterior emotion-cognition gradient and a self-world-centric gradient.
These gradients support the hippocampus's role in spatial navigation and episodic memory construction.
Openly available functional maps will aid future neuroscience research.