Related Experiment Video
Updated: Jan 29, 2026

Imaging Mycobacterium tuberculosis in Mice with Reporter Enzyme Fluorescence
Published on: February 26, 2018
Bidirectional association between tuberculosis and sarcoidosis.
Sheng-Huei Wang1, Chi-Hsiang Chung2,3, Tsai-Wang Huang4
1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Tuberculosis (TB) increases the risk of developing sarcoidosis eightfold. Sarcoidosis also elevates TB risk, particularly extrapulmonary TB, underscoring diagnostic challenges for these granulomatous diseases.
Area of Science:
- Pulmonology
- Infectious Diseases
- Immunology
Background:
- Tuberculosis (TB) and sarcoidosis are granulomatous diseases with uncertain interassociations.
- Clarifying the relationship between TB and sarcoidosis is crucial for clinical understanding.
Purpose of the Study:
- To investigate the bidirectional association between tuberculosis and sarcoidosis.
- To determine if TB is a risk factor for sarcoidosis and vice versa.
Main Methods:
- Retrospective longitudinal cohort study using Taiwan National Health Insurance Database (2000-2015).
- Two cohorts established: TB patients (n=31,221) vs. controls (n=62,442) for sarcoidosis risk; Sarcoidosis patients (n=2,442) vs. controls (n=9,688) for TB risk.
- Cox proportional hazards model adjusted for confounders.
Main Results:
- TB patients had an 8.09-fold higher risk of developing sarcoidosis.
- Sarcoidosis patients had a 1.85-fold higher risk of developing TB.
- Extrapulmonary TB was associated with the highest risk of developing sarcoidosis; sarcoidosis patients showed increased risk of extrapulmonary TB.
Conclusions:
- Tuberculosis is a significant risk factor for developing sarcoidosis.
- The bidirectional relationship highlights diagnostic complexities in differentiating or co-diagnosing TB and sarcoidosis.
More Related Videos
09:02An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei
Published on: February 17, 2014
12:17An In Vitro Caseum Binding Assay that Predicts Drug Penetration in Tuberculosis Lesions
Published on: May 8, 2017
Related Concept Videos
Association Areas of the Cortex
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Associative Learning
Classical conditioning, also known...
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories: