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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

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Published on: June 24, 2020

Histological chorioamnionitis at term according to labor onset: a prospective controlled study

Hadas Ganer Herman¹, Letizia Schreiber², Hadas Miremberg³

¹Department of Obstetrics & Gynecology, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, the Edith Wolfson Medical Center, Holon, Israel. hadassganer@yahoo.com.

Journal of Perinatology : Official Journal of the California Perinatal Association

|February 7, 2019

Summary

Histological chorioamnionitis (HCA) is common in spontaneous labor during term pregnancies. This finding suggests a link between inflammation and the onset of labor signals.

Area of Science:

Obstetrics and Gynecology
Perinatal Medicine
Pathology

Background:

Histological chorioamnionitis (HCA) is an intra-amniotic infection and inflammation.
The incidence of HCA in term pregnancies varies based on labor onset and delivery mode.
Understanding HCA's prevalence is crucial for managing term pregnancies.

Purpose of the Study:

To investigate the incidence of histological chorioamnionitis (HCA) in term pregnancies.
To compare HCA rates across different labor onset groups: spontaneous labor, pre-labor rupture of membranes (PROM), labor induction, and elective cesarean delivery.

Main Methods:

A prospective study involving 260 term pregnancy placentas from 2013-2016.
Placentas were analyzed histopathologically.
Comparison of HCA rates between four groups: spontaneous labor, PROM, labor induction, and elective cesarean delivery (CD).

Main Results:

HCA rates were significantly different across groups (p < 0.001).
Spontaneous labor group had the highest HCA rate (49%), followed by PROM (32%), labor induction (24%), and elective CD (4%).
Spontaneous labor onset and prolonged rupture of membranes (>12 hours) were independent risk factors for HCA.

Conclusions:

HCA is prevalent in term pregnancies with spontaneous labor.
Findings support the association between inflammatory processes and the physiological activation of parturition.
HCA incidence is influenced by the mode of labor onset and duration of membrane rupture.

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