Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Frequency-dependent Selection01:21

Frequency-dependent Selection

When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.Positive Frequency-Dependent SelectionIn positive...
Mate Choice01:20

Mate Choice

Mate choice—the decision about whom to mate with—is a type of natural selection, since animals must reproduce to pass down their genes. Mate choice is also called intersexual selection because the behavior occurs between the sexes.
Inclusive Fitness00:57

Inclusive Fitness

Most altruistic behavior—in which one animal helps another at a cost to themselves—occurs between relatives. Scientists think these altruistic behaviors evolved because they increase the inclusive fitness of the animal providing help.
Natural Selection and Mating Preferences01:06

Natural Selection and Mating Preferences

The principle of natural selection posits that organisms better adapted to their environment are more likely to survive and reproduce. This principle is closely intertwined with mating preferences, a key aspect of sexual selection, which evolutionary psychologists believe is driven by instincts to propagate one's genes. Such instincts significantly influence mating behaviors and preferences between genders.
Females, due to their biological roles in conception, pregnancy, and nursing, inherently...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Pedigree Analysis01:35

Pedigree Analysis

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dissecting the genetic and proteomic risk factors for delirium.

Nature aging·2025
Same author

Mendelian randomization study implicates inflammaging biomarkers in retinal vasculature, cardiovascular diseases, and longevity.

Science advances·2025
Same author

The future of polygenic risk scores in direct-to-consumer genomics.

Nature genetics·2025
Same author

Genetic score omics regression and multitrait meta-analysis detect widespread <i>cis</i>-regulatory effects shaping bovine complex traits.

PNAS nexus·2025
Same author

Data Resource Profile: Whole-Blood DNA Methylation Resource in Generation Scotland (MeGS).

International journal of epidemiology·2025
Same author

The Farm Animal Genotype-Tissue Expression (FarmGTEx) Project.

Nature genetics·2025

Related Experiment Video

Updated: Jun 16, 2026

Using Single-Worm Data to Quantify Heterogeneity in Caenorhabditis elegans-Bacterial Interactions
09:54

Using Single-Worm Data to Quantify Heterogeneity in Caenorhabditis elegans-Bacterial Interactions

Published on: July 22, 2022

3.6K

Indirect assortative mating for human disease and longevity.

Konrad Rawlik1, Oriol Canela-Xandri1,2, Albert Tenesa3,4

  • 1The Roslin Institute, Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Easter Bush Campus, Midlothian, Edinburgh, EH25 9RG, Scotland.

Heredity
|February 7, 2019
PubMed
Summary
This summary is machine-generated.

Partners may indirectly assort based on shared genetic factors influencing longevity and disease risk. This study found correlations between the parents of couples, suggesting indirect genetic assortment impacts health traits across generations.

More Related Videos

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
10:08

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Published on: May 18, 2022

4.0K
In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

14.2K

Related Experiment Videos

Last Updated: Jun 16, 2026

Using Single-Worm Data to Quantify Heterogeneity in Caenorhabditis elegans-Bacterial Interactions
09:54

Using Single-Worm Data to Quantify Heterogeneity in Caenorhabditis elegans-Bacterial Interactions

Published on: July 22, 2022

3.6K
Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
10:08

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Published on: May 18, 2022

4.0K
In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

14.2K

Area of Science:

  • Genetics and Epidemiology
  • Human Longevity and Disease Risk

Background:

  • Phenotypic correlations between partners for traits like longevity and disease are similar to those in first-degree relatives.
  • The mechanisms driving these correlations, particularly in later life, remain unclear.
  • Existing research lacks understanding of indirect assortment on heritable factors across generations.

Purpose of the Study:

  • To introduce a novel paradigm for detecting indirect assortment by examining correlations between parents of couples (in-laws).
  • To investigate indirect assortment on heritable factors influencing longevity and disease risk.
  • To analyze correlations in additive genetic values between parents of couples.

Main Methods:

  • Analysis of couples from the UK Biobank cohort to assess correlations in parental longevity and disease history.
  • Replication of parental longevity correlations using the FamiLinx cohort, a larger historical dataset.
  • Statistical analysis to compare observed correlations with expected variations based on birth year and location.

Main Results:

  • Significant correlations (up to 0.09) were observed between the longevity and disease history of parents of White British couples in the UK Biobank.
  • Parental longevity correlations were replicated in the FamiLinx cohort, exceeding chance variations.
  • Significant correlations (r=0.028, p<0.005) were found in genetic values for cardiovascular diseases, like hypertension, between partners.

Conclusions:

  • The findings support a model of indirect assortative mating, where partners may select each other based on genetically correlated risk factors for diseases like hypertension.
  • Indirect assortment on heritable factors appears to influence longevity and disease risk across generations.
  • Further research using large, longitudinal cohorts is needed to differentiate indirect assortative mating from shared environmental influences.