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Related Experiment Videos

Ketoprofen: the European experience.

B Avouac1, M Teule

  • 1Department of Rheumatology, Henri Mondor Hospital, Paris, France.

Journal of Clinical Pharmacology
|December 1, 1988
PubMed
Summary

Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), is effective for rheumatoid arthritis and osteoarthritis. It offers various dosage forms and demonstrates an excellent safety profile with low adverse event incidence.

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Area of Science:

  • Pharmacology
  • Rheumatology
  • Drug Safety

Background:

  • Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic properties.
  • Marketed in Europe since 1973, its extensive use provides a robust dataset for evaluation.

Purpose of the Study:

  • To provide an overview of European experience with ketoprofen.
  • To assess its efficacy, safety, and available dosage forms.

Main Methods:

  • Review of European postmarketing surveillance studies.
  • Analysis of French and British drug monitoring data.
  • Evaluation of clinical experience with various ketoprofen formulations.

Main Results:

  • Oral ketoprofen (200 mg/day) is effective for rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.
  • Available dosage forms include oral, intramuscular, suppositories, slow-release, and topical gel.
  • Ranked as one of the safest NSAIDs in the UK with a low incidence of serious gastrointestinal, renal, hepatic, or cutaneous reactions.

Conclusions:

  • Ketoprofen is an effective anti-inflammatory and analgesic agent.
  • It possesses an excellent safety profile, supported by extensive postmarketing data.
  • Multiple convenient dosage forms enhance its therapeutic utility.

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