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Metabolic Alterations in Cardiopulmonary Vascular Dysfunction.

Valérie Françoise Smolders1,2,3,4, Erika Zodda1,5, Paul H A Quax3,4

  • 1Department of Biochemistry and Molecular Biology and Institute of Biomedicine (IBUB), Faculty of Biology, University of Barcelona, Barcelona, Spain.

Frontiers in Molecular Biosciences
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PubMed
Summary

Cardiovascular diseases involve endothelial dysfunction linked to altered cell metabolism, specifically increased glycolysis (Warburg effect). Targeting this metabolic shift offers a promising therapeutic strategy for heart and blood vessel conditions.

Keywords:
acute myocardial infarctioncellular metabolismendothelial dysfunctionglycolysismetabolic targetspulmonary hypertensionsystems biology

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Area of Science:

  • Cardiovascular Science
  • Cellular Metabolism
  • Endothelial Biology

Background:

  • Cardiovascular diseases (CVD) are a leading global cause of death.
  • CVD, including acute myocardial infarction (AMI) and pulmonary hypertension (PH), share features like narrowed blood vessels and tissue damage.
  • Endothelial dysfunction is a key factor in CVD development and progression.

Purpose of the Study:

  • To review the endothelium's role in vascular homeostasis.
  • To detail endothelial cell metabolism and its alterations in CVD.
  • To explore targeting endothelial metabolism as a therapeutic strategy for cardiopulmonary vascular dysfunction.

Main Methods:

  • Literature review focusing on endothelial cell metabolism.
  • Analysis of metabolic alterations in acute myocardial infarction and pulmonary hypertension.
  • Discussion of current research on pharmacological modulation of cellular metabolism.

Main Results:

  • Endothelial cells in CVD may exhibit a metabolic switch to increased glycolysis (Warburg effect).
  • Abnormal endothelial metabolism contributes to vascular dysfunction in AMI and PH.
  • Understanding endothelial metabolism is crucial for identifying novel biomarkers and therapeutic targets.

Conclusions:

  • Targeting endothelial cell metabolism is an emerging and promising therapeutic avenue for CVD.
  • Restoring normal endothelial function through metabolic interventions may help prevent or reverse CVD.
  • Personalized, multi-target metabolic interventions show potential for treating cardiovascular diseases.