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Related Concept Videos

Heritability01:06

Heritability

657
Heritability is a statistical concept that measures the degree to which genetic differences among individuals contribute to trait variations within a population. It is a fundamental idea in genetics, often prone to misinterpretation. Heritability is expressed as a percentage, reflecting the proportion of variation in a specific trait across a population that can be linked to genetic differences. However, it's important to understand that heritability does not determine how "genetic"...
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What is Natural Selection?01:32

What is Natural Selection?

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Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.
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Chromosomal Theory of Inheritance01:39

Chromosomal Theory of Inheritance

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In 1866, Gregor Mendel published the results of his pea plant breeding experiments, providing evidence for predictable patterns in the inheritance of physical characteristics. The significance of his findings was not immediately recognized. In fact, the existence of genes was unknown at the time. Mendel referred to hereditary units as “factors.”
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Related Experiment Video

Updated: Jan 29, 2026

Environmentally Induced Heritable Changes in Flax
08:10

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Published on: January 26, 2011

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Heritability in frontotemporal tauopathies.

Shelley L Forrest1, Glenda M Halliday2,3,4, Heather McCann3

  • 1Faculty of Medicine and Health, Charles Perkins Centre and Discipline of Pathology, University of Sydney, Sydney, Australia.

Alzheimer'S & Dementia (Amsterdam, Netherlands)
|February 7, 2019
PubMed
Summary
This summary is machine-generated.

Heritability in frontotemporal lobar degeneration with tau (FTLD-tau) varies by subtype. Globular glial tauopathy showed the highest heritability, suggesting genetic factors influence FTLD-tau pathogenesis.

Keywords:
Family historyFrontotemporal degenerationMAPTPathologyTau

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Area of Science:

  • Neuroscience
  • Genetics
  • Pathology

Background:

  • Frontotemporal lobar degeneration with tau-immunopositive inclusions (FTLD-tau) is a neurodegenerative disease.
  • Understanding the genetic basis of FTLD-tau is crucial for elucidating disease pathogenesis.

Purpose of the Study:

  • To investigate the heritability of FTLD-tau in a large cohort.
  • To determine if specific FTLD-tau subtypes exhibit stronger heritability.

Main Methods:

  • Utilized modified Goldman pedigree classifications to assess heritability.
  • Analyzed pathologically confirmed FTLD-tau cases (n=124) from the Sydney-Cambridge collection.

Main Results:

  • 13% of the FTLD-tau cohort showed a suggested autosomal dominant inheritance pattern; 25% had a family history.
  • Globular glial tauopathy displayed the highest heritability (40% suggested autosomal dominant inheritance), followed by corticobasal degeneration (19%), Pick's disease (8%), and progressive supranuclear palsy (6%).
  • MAPT mutations were identified in 9% of cases.

Conclusions:

  • Heritability in FTLD-tau is not uniform and differs across pathological subtypes.
  • Further research is needed to identify specific genetic links in FTLD-tau cases with high heritability.