Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Renal Clearance01:23

Renal Clearance

2.6K
The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
2.6K
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

458
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
458
Renal Drug Clearance: Overview01:06

Renal Drug Clearance: Overview

749
Renal clearance is a crucial parameter in pharmacokinetics that quantifies the rate at which the kidneys excrete a drug. It represents a constant fraction of the central volume of distribution containing the drug that the kidney eliminates per unit of time.
Renal clearance can be calculated using different methods. One approach is to divide the urinary drug excretion rate by the plasma drug concentration. This method directly measures renal clearance, indicating the kidneys' efficiency in...
749
Renal Drug Clearance: Comparison Between Renal Excretion Methods01:08

Renal Drug Clearance: Comparison Between Renal Excretion Methods

605
Renal clearance is a critical parameter encompassing kidney filtration, secretion, and reabsorption processes. It is calculated using a specific equation to determine the rate at which the kidneys clear a drug.
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
605
Factors Affecting Renal Clearance: Drug Distribution and Drug Interactions01:09

Factors Affecting Renal Clearance: Drug Distribution and Drug Interactions

531
Renal clearance plays a pivotal role in drug elimination from the body and can be influenced by drug distribution and interactions. Understanding these factors is crucial in pharmacology as they impact the effectiveness and duration of drug therapy.
One important factor is the relationship between renal clearance and the apparent volume of distribution. Renal clearance tends to be inversely proportional to the apparent volume of distribution. Drugs with an extensive distribution volume or those...
531
Determination of Renal Drug Clearance: Graphical and Midpoint Methods01:07

Determination of Renal Drug Clearance: Graphical and Midpoint Methods

394
Renal clearance, a crucial parameter in pharmacokinetics, can be determined using two different methods: the graphical method and the midpoint method. These methods provide insights into the rate of drug excretion by the kidneys and aid in assessing renal function.
The graphical method involves plotting the rate of drug excretion in urine against the plasma drug concentration. By analyzing the graph, the clearance can be calculated and obtained. Drugs rapidly excreted by the kidneys exhibit a...
394

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Importance of Residency Training for the Provision of Comprehensive Clinical Pharmacy Services.

Journal of the American College of Clinical Pharmacy : JACCP·2026
Same author

Prevalence and prediction of augmented renal clearance in the neurocritical care population.

Journal of neurocritical care·2026
Same author

Pharmacist's Guide to Common Intracranial Bleeding Terms and Treatments.

The Annals of pharmacotherapy·2025
Same author

Update on Neuroprotection after Traumatic Brain Injury.

CNS drugs·2025
Same author

Personalized antiseizure medication therapy in critically ill adult patients.

Pharmacotherapy·2023
Same author

Comparison of nimodipine formulations and administration techniques via enteral feeding tubes in patients with aneurysmal subarachnoid hemorrhage: A multicenter retrospective cohort study.

Pharmacotherapy·2023
Same journal

The Effect of Multiple Doses of Itraconazole on the Pharmacokinetics of a Single Oral Dose of Zongertinib in Healthy Male Volunteers.

Pharmacotherapy·2026
Same journal

Menopausal Hormone Therapy: A Narrative Review of Contemporary Evidence.

Pharmacotherapy·2026
Same journal

Getting It Right the Second Time: How Can we Optimize First-Generation Cephalosporin Dosing for Skin and Soft Tissue Infections in the 21st Century?

Pharmacotherapy·2026
Same journal

Buprenorphine Initiation During Extracorporeal Membrane Oxygenation Decreases Sedative and Opioid Exposure: A Retrospective Matched Case-Control Study.

Pharmacotherapy·2026
Same journal

Voriconazole Dosing and Therapeutic Drug Monitoring in Patients Before and After Liver Transplantation.

Pharmacotherapy·2026
Same journal

Quantifying the Serum Magnesium Response and Predictors of Response Following Intravenous Magnesium Replacement in Critically Ill Patients.

Pharmacotherapy·2026
See all related articles

Related Experiment Video

Updated: Jan 29, 2026

Direct Drug Delivery to Kidney via the Renal Artery
11:18

Direct Drug Delivery to Kidney via the Renal Artery

Published on: April 17, 2021

8.2K

Augmented Renal Clearance.

Aaron M Cook1,2, Jimmi Hatton-Kolpek2

  • 1UKHealthcare, Pharmacy Services, University of Kentucky, Lexington, Kentucky.

Pharmacotherapy
|February 7, 2019
PubMed
Summary
This summary is machine-generated.

Augmented renal clearance (ARC) in critically ill patients leads to faster drug elimination, risking treatment failure. Recognizing and managing ARC is crucial for optimizing medication dosing and improving patient outcomes.

Keywords:
antiepileptic drugscritical carepharmacokineticsseptic shockβ-lactams

More Related Videos

Use of a Hanging-weight System for Isolated Renal Artery Occlusion
07:54

Use of a Hanging-weight System for Isolated Renal Artery Occlusion

Published on: July 19, 2011

16.5K
A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection
06:59

A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection

Published on: February 2, 2022

4.5K

Related Experiment Videos

Last Updated: Jan 29, 2026

Direct Drug Delivery to Kidney via the Renal Artery
11:18

Direct Drug Delivery to Kidney via the Renal Artery

Published on: April 17, 2021

8.2K
Use of a Hanging-weight System for Isolated Renal Artery Occlusion
07:54

Use of a Hanging-weight System for Isolated Renal Artery Occlusion

Published on: July 19, 2011

16.5K
A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection
06:59

A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection

Published on: February 2, 2022

4.5K

Area of Science:

  • Critical Care Medicine
  • Pharmacology
  • Nephrology

Background:

  • Augmented renal clearance (ARC) involves elevated creatinine clearance in critically ill patients.
  • Patients with severe neurologic injury, sepsis, trauma, and burns are at high risk for ARC.
  • ARC can lead to increased elimination of renally cleared medications.

Purpose of the Study:

  • To review the clinical characteristics and identification methods for patients at risk of ARC.
  • To discuss potential mechanisms contributing to ARC.
  • To outline pharmacotherapy dosing considerations for patients with ARC.

Main Methods:

  • Literature review of studies on augmented renal clearance in critically ill patients.
  • Analysis of mechanisms contributing to increased renal clearance.
  • Examination of pharmacotherapy dosing strategies in the context of ARC.

Main Results:

  • ARC is characterized by creatinine clearances often exceeding 170 ml/minute.
  • Potential mechanisms include increased metabolism, altered neurohormonal balance, and fluid resuscitation.
  • ARC is linked to suboptimal drug exposure, particularly with beta-lactams and vancomycin.

Conclusions:

  • Vigilance is required by critical care pharmacists to identify ARC as a factor in treatment outcomes.
  • Optimizing drug dosing in critically ill patients with ARC is an ongoing research objective.
  • Understanding ARC is essential for effective medication management in critical care settings.