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Drug resistance-related microRNAs in osteosarcoma: Translating basic evidence into therapeutic strategies

Ruiling Chen1, Gangyang Wang1, Ying Zheng1

  • 1Department of Orthopedics, Shanghai Bone Tumor Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Journal of Cellular and Molecular Medicine
|February 7, 2019
PubMed

Insights

Multidrug resistance (MDR) challenges osteosarcoma treatment. MicroRNAs (miRNAs) play a key role in MDR, offering potential biomarkers and therapeutic targets for improved patient outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Osteosarcoma treatment faces challenges due to multidrug resistance (MDR).
  • MicroRNAs (miRNAs) are increasingly recognized for their role in cancer development and drug resistance.
  • Understanding miRNA-mediated mechanisms is crucial for overcoming treatment refractoriness in osteosarcoma.

Purpose of the Study:

  • To review the molecular mechanisms of miRNA-regulated drug resistance in osteosarcoma.
  • To highlight the potential of miRNAs as predictive biomarkers for osteosarcoma patient outcomes.
  • To explore therapeutic strategies targeting miRNAs to reverse drug resistance.

Main Methods:

  • Literature review of studies on microRNAs and osteosarcoma multidrug resistance.
  • Analysis of mechanisms including DNA damage response, apoptosis, autophagy, cancer stem cells, and signal transduction.
  • Synthesis of evidence linking specific miRNAs to drug resistance phenotypes.

Main Results:

  • MicroRNAs are implicated in key processes contributing to osteosarcoma MDR.
  • Specific miRNAs are associated with poor prognosis and reduced survival in osteosarcoma patients.
  • miRNAs demonstrate potential as targets for novel therapeutic interventions.

Conclusions:

  • MicroRNAs are significant regulators of multidrug resistance in osteosarcoma.
  • Targeting miRNAs offers a promising avenue for developing predictive biomarkers and therapeutic strategies.
  • Further research into miRNA-mediated pathways can improve osteosarcoma treatment efficacy.
Keywords:
biomarkerdrug resistancemiRNAosteosarcomatherapeutic target

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