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Predicting Catalyst Extrudate Breakage Based on the Modulus of Rupture
Published on: May 13, 2018
N-Fluorobenzenesulfonimide as a highly effective Ag(i)-catalyst attenuator for tryptamine-derived ynesulfonamide
Yadong Pang1, Guoduan Liang, Fukai Xie
1Key Laboratory of Structure-Based Drug Design and Discovery Shenyang Pharmaceutical University, Ministry of Education, Shenyang 110016, P. R. China. randybinlin@gmail.com yongxiang.liu@syphu.edu.cn.
Abstract:
N-Fluorobenzenesulfonimide (NFSI) was identified for the first time as a highly effective Ag(i)-catalyst attenuator in the annulation of a tryptamine-derived ynesulfonamide to azepino[4,5-b]indole derivatives. Substrate tolerances were examined thoroughly and a plausible mechanism was proposed. The interaction between the Ag(i) catalyst and NFSI was probed by density functional theory (DFT) calculations. This study provided a highly efficient method to synthesize azepino[4,5-b]indole derivatives.
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