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Pholiotone A, a new polyketide derivative from Pholiota sp
Yingchao He1, Renlei Wang2, Bin Huang2
1Clinical Medical College of Fujian Provincial Hospital, Fujian Medical University/Fujian provincial Hospital, Fuzhou, People's Republic of China.
Natural Product Research
|February 7, 2019
Summary
Researchers discovered Pholiotone A, a novel polyketide, from *Pholiota* mushrooms. Its structure was elucidated, and its antifungal and cytotoxic activities were assessed alongside known compounds.
Area of Science:
- Natural Product Chemistry
- Mycology
- Organic Chemistry
Background:
- The mushroom *Pholiota* sp. is a source of diverse bioactive compounds.
- Polyketide derivatives often exhibit significant biological activities.
Purpose of the Study:
- To isolate and characterize new compounds from *Pholiota* sp.
- To evaluate the antifungal and cytotoxic potential of isolated compounds.
Main Methods:
- Isolation of compounds using chromatography.
- Structure elucidation via Nuclear Magnetic Resonance (NMR) spectroscopy.
- Determination of stereochemistry using the modified Mosher method and electronic circular dichroism (ECD) calculations.
Main Results:
- Pholiotone A, a new tetrahydrobenzofuran-4(2H)-one derivative, was identified.
- Four known compounds (trichodermatides A, B; koninginins B, E) were also isolated.
- Antifungal and cytotoxicity assays were performed on all five compounds.
Conclusions:
- Pholiotone A represents a novel polyketide structure.
- The isolated compounds from *Pholiota* sp. warrant further investigation for therapeutic applications.
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