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Updated: Jan 29, 2026
06:26
Pre-clinical Model of Cardiac Donation after Circulatory Death
Published on: August 2, 2019
8.4K
Organ donation after circulatory death: current status and future potential
Martin Smith1, B Dominguez-Gil2, D M Greer3
1Neurocritical Care Unit, The National Hospital for Neurology and Neurosurgery, University College London Hospitals, Queen Square, London, UK. martin.smith@ucl.ac.uk.
Intensive Care Medicine
|February 7, 2019
Summary
Donation after circulatory death (DCD) offers a vital solution to organ shortages, with survival rates comparable to brain death donation. Advanced preservation techniques are crucial for maximizing the viability of DCD organs.
Area of Science:
- Transplantation medicine
- Organ donation and procurement
- Medical ethics and policy
Background:
- Persistent shortage of deceased donor organs for transplantation.
- Limited availability of donors after brain death necessitates alternative strategies.
- Resurgence of interest in donation after circulatory death (DCD) due to organ scarcity.
Purpose of the Study:
- To review current donation after circulatory death (DCD) pathways and their effectiveness.
- To explore strategies for minimizing ischemia and improving DCD organ viability.
- To discuss ethical, professional, and legal frameworks supporting DCD programs.
Main Methods:
- Review of controlled and uncontrolled DCD pathways.
- Analysis of in situ organ preservation and ex situ resuscitation techniques.
- Examination of national ethical, professional, and legal frameworks for DCD.
Main Results:
- Transplantation survival after DCD is comparable to donation after brain death.
- Higher rates of primary non-function and delayed graft function observed in DCD.
- Well-organized DCD pathways and advanced preservation techniques minimize ischemia.
Conclusions:
- Expanding standard DCD programs alone is insufficient to meet global organ demand.
- Increased reliance on extended criteria donors necessitates minimizing ischemic injury.
- Normothermic regional perfusion and ex situ perfusion enhance organ quality and reduce discard.
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