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N/OFQ-NOP System and Airways
Bruno D'Agostino1, Manuela Sgambato2, Renata Esposito2
1Department of Experimental Medicine, Section of Pharmacology L. Donatelli, University of Campania "L. Vanvitelli", Naples, Italy. bruno.dagostino@unicampania.it.
Handbook of Experimental Pharmacology
|February 7, 2019
Summary
The Nociceptin/OFQ-NOP receptor system shows potential for treating asthma by reducing airway inflammation and hyperresponsiveness. Supplementation with Nociceptin/OFQ may be beneficial for severe asthma patients.
Area of Science:
- Immunology
- Pharmacology
- Respiratory Medicine
Background:
- Asthma is a chronic airway inflammatory disease, with atopic asthma triggered by allergens.
- Key symptoms include breathlessness, hyperresponsiveness, wheezing, and coughing.
- The Nociceptin/OFQ-NOP receptor system exhibits anti-hyperresponsiveness and immunomodulatory properties.
Purpose of the Study:
- To investigate the role of the Nociceptin/OFQ-NOP receptor system in asthma.
- To explore its potential as a therapeutic target for managing airway inflammation and hyperresponsiveness.
Main Methods:
- Analysis of Nociceptin/OFQ levels in asthmatic patients' sputum.
- In vitro experiments adding exogenous Nociceptin/OFQ to sputum from severe asthma patients.
- Assessment of effects on eosinophil migration and inflammatory mediator release.
Main Results:
- Elevated Nociceptin/OFQ levels in asthmatic sputum correlate with increased eosinophil counts.
- Exogenous Nociceptin/OFQ attenuated eosinophil migration and inflammatory mediator release in severe asthma sputum.
- Endogenous Nociceptin/OFQ levels were insufficient for therapeutic benefit, suggesting a need for supplementation.
Conclusions:
- The Nociceptin/OFQ-NOP receptor system plays a significant role in modulating airway inflammation and hyperresponsiveness in asthma.
- Exogenous Nociceptin/OFQ demonstrates therapeutic potential by inhibiting key inflammatory processes.
- Targeting this system offers novel strategies for asthma treatment.
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