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Methionine Restriction and Life-Span Extension.

Robert M Hoffman1,2

  • 1AntiCancer, Inc., San Diego, CA, USA. all@anticancer.com.

Methods in Molecular Biology (Clifton, N.J.)
|February 7, 2019
PubMed
Summary

Methionine restriction (MR) extends animal lifespan, mirroring caloric restriction benefits. This dietary approach shows promise for reversing metabolic syndrome, including diabetes and obesity, and can be enhanced with oral methioninase.

Keywords:
AgingDiabetesLife-span extensionMethioninaseMethionine restrictionObesityOral delivery

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Area of Science:

  • Gerontology and Metabolic Health

Background:

  • Caloric restriction (CR) has been known for nearly a century to extend lifespan in various animal models.
  • Methionine restriction (MR) emerged approximately 25 years ago as a dietary intervention with similar life-extending properties to CR.

Purpose of the Study:

  • To summarize the multifaceted effects of methionine restriction (MR) on healthspan and lifespan.
  • To explore MR's impact on the reversal of metabolic syndrome components, including diabetes and obesity.
  • To investigate the efficacy of orally delivered methioninase as a method for methionine restriction.

Main Methods:

  • Review and summarization of existing research on methionine restriction.
  • Exploration of the physiological mechanisms underlying MR's effects.
  • Assessment of orally-administered methioninase as a practical delivery method for MR.

Main Results:

  • Methionine restriction (MR) has been shown to extend the normal lifespan of animals.
  • MR demonstrates significant effects in reversing key aspects of the metabolic syndrome, such as diabetes and obesity.
  • Oral delivery of methioninase is presented as an effective strategy for implementing MR.

Conclusions:

  • Methionine restriction (MR) is a potent dietary intervention with broad health benefits, including lifespan extension.
  • MR offers a viable strategy for managing and potentially reversing metabolic disorders like diabetes and obesity.
  • The use of orally delivered methioninase provides a practical and effective means to achieve MR.