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Microglia in Alzheimer's disease: A target for immunotherapy
Shoutang Wang1, Marco Colonna1
1Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri, USA.
Journal of Leukocyte Biology
|February 7, 2019
Abstract:
Microglia are resident Mϕs of the CNS that play pleiotropic functions in brain development and homeostasis. Impaired microglial functions are thought to be involved in the onset and progression of various neurodevelopmental and neurodegenerative diseases. Thus, understanding microglia in these settings may indicate new approaches for therapeutic intervention. Here, we review recent evidence implicating microglia in Alzheimer's disease and discuss potential therapeutic strategies targeting microglia and their receptors in this disease.