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Area of Science:

  • Psychopharmacology
  • Neuroscience
  • Mental Health Research

Background:

  • Microdosing, the regular ingestion of sub-perceptual doses of psychedelic substances, has gained significant popularity.
  • Anecdotal reports suggest widespread well-being and health benefits, yet empirical evidence is scarce.
  • Investigating microdosing is challenging due to legal and bureaucratic restrictions on psychedelic research.

Purpose of the Study:

  • To systematically investigate the self-reported psychological effects of microdosing in individuals.
  • To examine the influence of expectations and beliefs on perceived microdosing outcomes.
  • To identify areas for future dose-controlled empirical research on microdosing.

Main Methods:

  • Study One: Observational investigation of 98 microdosers over six weeks, including daily psychological functioning ratings and psychometric assessments.
  • Study Two: Survey of 263 individuals (naïve and experienced) to assess pre-existing beliefs and expectations regarding microdosing effects.
  • Utilized daily ratings, psychometric batteries (mood, attention, wellbeing, personality), and expectancy bias measures.

Main Results:

  • Daily ratings indicated improved psychological functioning on dosing days, with minimal carry-over effects.
  • Pre- and post-study measures showed reduced depression and stress, decreased distractibility, increased absorption, and heightened neuroticism.
  • Study Two revealed a significant discrepancy between expected benefits and reported outcomes, highlighting expectancy bias.

Conclusions:

  • Microdosing appears to enhance psychological functioning acutely but has limited residual effects.
  • Expectations significantly influence perceived microdosing benefits, often exceeding actual reported outcomes.
  • Further dose-controlled empirical research is crucial to understand microdosing's impact on mental health and cognition.