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[Pre-extensively drug-resistant congenital tuberculosis: case report]

Hernán Del Castillo1, Antonio Salas Lopez2, Anna Paredes Temoche3

  • 1Instituto Nacional de Salud del Niño. Lima, Perú.

Revista Peruana De Medicina Experimental Y Salud Publica
|February 7, 2019
PubMed

Insights

Congenital tuberculosis is challenging to diagnose in infants, often requiring consideration of maternal history. Early suspicion and treatment are crucial for favorable outcomes in neonates with suspected tuberculosis.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Neonatology

Background:

  • Congenital tuberculosis presents diagnostic challenges in infants due to non-specific symptoms and often negative standard test results.
  • Identifying the source of transmission in infant tuberculosis cases can be difficult.

Observation:

  • A one-month-old infant presented with irritability, tachypnea, fever, poor weight gain, and hepatomegaly.
  • The infant's mother had a history of pre-extensively drug-resistant tuberculosis and placental findings indicative of Mycobacterium tuberculosis.

Findings:

  • The infant was diagnosed with suspected congenital tuberculosis based on clinical signs and maternal history.
  • Treatment resulted in a favorable clinical evolution and no adverse reactions.

Implications:

  • Congenital tuberculosis diagnosis should be considered in infants presenting with suggestive clinical signs.
  • A maternal history of Mycobacterium tuberculosis infection warrants maintaining a high index of suspicion for congenital tuberculosis.

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