[Disbalance of redox processes in amniotic fluid at pre-eclampsia.]

The parameters of pro and antioxidant processes in the amniotic fluid in the dynamics of physiological pregnancy and preeclampsia were studied. Spectrophotometric and fluorimetric methods were used to evaluate the activity of NADPH-oxidase, xanthine-oxidase, superoxide dismutase (SOD), catalase, glutathione-dependent enzyme systems, the content of antioxidant vitamins - retinol and α-tocopherol, lipid peroxidation products (LPP) - diene conjugates and Schiff bases, and parameters of peroxide chemiluminescence. It was found that with preeclampsia there is an increase in the activity of prooxidant enzymes NADPH-oxidase and xanthine-oxidase, a decrease in the activity of antioxidant enzymes SOD, catalase, glutathione peroxidase, glutathione reductase, glutathione transferase, and the content of fat-soluble vitamins. Between pro- and antioxidant indices and the content of LPP, intensity of chemiluminescence a correlation is established, the degree of which is different in the II and III trimesters of pregnancy. The revealed changes obviously play a pathogenetic role in the formation and further development of preeclampsia, and the indicators of oxidation-reduction processes can serve as informative markers of pre- and postnatal pathology.