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Updated: Jan 29, 2026

Acute Myocardial Infarction in Rats
Published on: February 16, 2011
Galectin-3 in Acute Myocardial Infarction Patients with Atrial Fibrillation
Dragana Stanojevic1, Svetlana Apostolovic2,3, Dragana Stokanovic4
1Clinic for Cardiovascular Diseases, Clinical Centre Nis, Nis, Serbia, draganastanojevic1@gmail.com.
Objective:
Atrial fibrillation (AF) is common in acute myocardial infarction (AMI), and galectin-3 is possibly involved in its occurrence. Galectin-3 has been shown to play a central role in fibrosis and tissue remodeling and has a role in inflammatory and proliferative responses. The aim of our study was to measure galectin-3 levels in patients with myocardial infarction and to compare its levels in patients with or without AF, in order to investigate the potential predictive role of galectin-3 in this setting.
Subjects And Methods:
The study included 51 consecutive AMI patients with AF; 27 AMI patients (52.9%) had permanent/persistent AF, and 24 patients (47.1%) had paroxysmal AF. Thirty-eight consecutive AMI patients without AF were used as a control group. Blood samples were obtained from venous blood on the third day after reperfusion.
Results:
Patients with AF had higher levels of C-reactive protein (p < 0.01) and galectin-3 (p < 0.05) than those without AF. Patients with high galectin-3 had 4.4 times greater odds of having AF. Galectin-3 levels were lower in patients without AF (p < 0.01) than in those with permanent/persistent AF.
Conclusion:
AMI patients with AF had higher levels of galectin-3 than those without this arrhythmia. This biomarker of inflammation and fibrosis could be a potential target for treating AMI patients at high risk.
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