Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH301:11

ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3

7.5K
All ortho–para directors, excluding halogens, are activating groups. These groups donate electrons to the ring, making the ring carbons electron-rich. Consequently, the reactivity of the aromatic ring towards electrophilic substitution increases. For instance, the nitration of anisole is about 10,000 times faster than the nitration of benzene. The electron-donating effect of the methoxy group in anisole activates the ortho and para positions on the ring and stabilizes the corresponding...
7.5K
Piaget's Stage 3 of Cognitive Development01:17

Piaget's Stage 3 of Cognitive Development

1.1K
During Piaget's concrete operational stage, from ages 7 to 11, children exhibit a marked increase in logical thinking skills, specifically in relation to tangible, real-world events. This stage is characterized by the development of several essential cognitive concepts, including conservation, reversibility, and classification, all of which support the child's evolving capacity for structured thought.
Conservation and Constancy of Quantity
A significant cognitive milestone in the...
1.1K
Patient-centered Care01:13

Patient-centered Care

3.0K
Patient-centered care involves delivering care beyond inpatient hospitalization. Reflective practice can enhance a patient-centered approach. Reflective practice is a process of reasoning that considers all aspects of the present situation, including practicalities, learning from personal practice, and consideration of patient needs. Patients appreciate care decisions made while considering their input. Involving the patient in their care provides the patient with a sense of contribution rather...
3.0K
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

269
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
269
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

263
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
263
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

660
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
660

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distinct Clinical Phenotypes in Moyamoya Disease: A Multicenter Comparison of Ischemic and Hemorrhagic Presentations.

Neurosurgery·2026
Same author

International multi-center study to quantify the effect of deep venous drainage after surgical resection of Spetzler-Martin Grade II-III brain arteriovenous malformations.

Neurosurgical review·2026
Same author

Woven Endobridge device for ruptured vs. unruptured aneurysms: insights from the WorldWideWEB study.

Neuroradiology·2026
Same author

Direct Versus Indirect Bypass in Early-Stage Moyamoya (Suzuki I-III): A Propensity Score-Weighted Study.

Translational stroke research·2026
Same author

Safety and long-term outcomes following bypass surgery in pediatric versus adult patients with Moyamoya disease: a multicenter cohort study.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2026
Same author

Intra-Arterial Thrombolytic vs. Mechanical Thrombectomy in Distal Medium Middle Cerebral Artery Acute Ischemic Stroke: A Preliminary Multinational Multicenter Propensity Score-Matched Study.

Clinical neuroradiology·2026
Same journal

Defining the Therapeutic Ceiling of Endovascular Thrombectomy in Large-Core Stroke: Beyond the Limits of ASPECTS.

Stroke·2026
Same journal

Adjunctive Normobaric Hyperoxia With Endovascular Thrombectomy for Acute Stroke at 6 to 24 Hours: A Phase IIb Randomized Trial.

Stroke·2026
Same journal

Management of Patients at Risk of Ischemic Stroke With Left Ventricular Systolic Dysfunction in the Absence of Intracardiac Thrombus: A Scientific Statement From the American Heart Association.

Stroke·2026
Same journal

Update on Rehabilitation After Stroke: Global Changes and the Continued Importance of Therapy Intensity, Dose, and Timing.

Stroke·2026
Same journal

ENTF Neuromodulation Yields Reduced Disability After Stroke: An Individual Participant-Level Data Meta-Analysis.

Stroke·2026
Same journal

Menopause and Its Implications for Stroke in Women.

Stroke·2026
See all related articles

Related Experiment Video

Updated: Jan 29, 2026

Hyaluronic-Acid Based Hydrogels for 3-Dimensional Culture of Patient-Derived Glioblastoma Cells
08:35

Hyaluronic-Acid Based Hydrogels for 3-Dimensional Culture of Patient-Derived Glioblastoma Cells

Published on: August 24, 2018

13.6K

DEFUSE 3 Non-DAWN Patients.

Thabele M Leslie-Mazwi1, Scott Hamilton2, Michael Mlynash2

  • 1From the Neuroscience Institute, Massachusetts General Hospital, Boston (T.M.L.-M., A.B.P., L.H.S., J.A.H.).

Stroke
|February 8, 2019
PubMed
Summary
This summary is machine-generated.

Endovascular thrombectomy benefits patients with large vessel occlusions, even those excluded from the DAWN trial due to infarct core size. These findings suggest more inclusive criteria for stroke treatment selection may be warranted.

Keywords:
brainbrain ischemiahumansstandard of carethrombectomy

More Related Videos

Establishing 3-Dimensional Spheroids from Patient-Derived Tumor Samples and Evaluating their Sensitivity to Drugs
10:38

Establishing 3-Dimensional Spheroids from Patient-Derived Tumor Samples and Evaluating their Sensitivity to Drugs

Published on: December 16, 2022

2.8K
Monovalent Cation Doping of CH3NH3PbI3 for Efficient Perovskite Solar Cells
08:30

Monovalent Cation Doping of CH3NH3PbI3 for Efficient Perovskite Solar Cells

Published on: March 19, 2017

17.2K

Related Experiment Videos

Last Updated: Jan 29, 2026

Hyaluronic-Acid Based Hydrogels for 3-Dimensional Culture of Patient-Derived Glioblastoma Cells
08:35

Hyaluronic-Acid Based Hydrogels for 3-Dimensional Culture of Patient-Derived Glioblastoma Cells

Published on: August 24, 2018

13.6K
Establishing 3-Dimensional Spheroids from Patient-Derived Tumor Samples and Evaluating their Sensitivity to Drugs
10:38

Establishing 3-Dimensional Spheroids from Patient-Derived Tumor Samples and Evaluating their Sensitivity to Drugs

Published on: December 16, 2022

2.8K
Monovalent Cation Doping of CH3NH3PbI3 for Efficient Perovskite Solar Cells
08:30

Monovalent Cation Doping of CH3NH3PbI3 for Efficient Perovskite Solar Cells

Published on: March 19, 2017

17.2K

Area of Science:

  • Neurology
  • Interventional Neurology
  • Stroke Medicine

Background:

  • The DAWN and DEFUSE 3 trials established thrombectomy for emergent large vessel occlusions (ELVOs) within 6 to 24 hours.
  • DEFUSE 3 included a broader patient population than DAWN.
  • This study evaluates thrombectomy outcomes in DEFUSE 3 patients who did not meet DAWN trial eligibility criteria.

Purpose of the Study:

  • To assess the efficacy of endovascular thrombectomy in DEFUSE 3 participants excluded from the DAWN trial.
  • To identify specific DAWN exclusion criteria (large infarct core, NIHSS 6-9, mRS 2) impacting DEFUSE 3 patients.
  • To compare outcomes between subgroups of DEFUSE 3 non-DAWN patients and the overall DEFUSE 3 cohort.

Main Methods:

  • DAWN trial eligibility criteria were applied to DEFUSE 3 patient data.
  • Patients meeting DEFUSE 3 criteria but not DAWN criteria were identified (DEFUSE 3 non-DAWN).
  • Outcomes and complications were compared between subgroups (e.g., core too large, NIHSS 6-9) and the entire DEFUSE 3 cohort.

Main Results:

  • 71 DEFUSE 3 patients did not meet DAWN criteria (31 with NIHSS 6-9, 33 with large core, 13 with mRS 2).
  • Patients with infarct core too large for DAWN criteria had significantly larger 24-hour infarct volumes (119 mL vs. 31.5 mL).
  • Thrombectomy showed a significant benefit in functional outcomes for the 'core too large' subgroup (OR, 20.9) and a trend for the NIHSS 6-9 subgroup (OR, 1.86).

Conclusions:

  • Endovascular therapy benefits patients with core infarct volumes <70 mL, even if considered too large by DAWN criteria.
  • More inclusive core infarct volume thresholds may be appropriate for patient selection in thrombectomy.
  • While thrombectomy benefits the overall DEFUSE 3 population, the benefit in the NIHSS 6-9 subgroup requires further investigation due to small sample size.