Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cognitive Dissonance01:38

Cognitive Dissonance

37.5K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
37.5K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

3.5K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.5K
Language and Cognition01:27

Language and Cognition

797
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
797
Cognitive Therapy01:25

Cognitive Therapy

1.0K
Cognitive therapy, pioneered by Aaron T. Beck in the 1960s, is a structured approach to addressing psychological distress by focusing on the influence of thoughts on emotions and behaviors. All cognitive therapies involve the basic assumption that human beings have control over their feelings, and that how individuals feel about something depends on how they think about it. Unlike psychoanalytic methods that delve into unconscious processes or humanistic approaches emphasizing...
1.0K
Cognition and Behavior01:23

Cognition and Behavior

369
Social psychology examines the complex interplay between individual mental processes and social interactions. Historically, the field was divided into two domains: social behavior and social cognition. Researchers focusing on social behavior analyzed actions within social contexts, such as conformity, aggression, or cooperation. Meanwhile, social cognition researchers investigated how people perceive, interpret, and mentally represent their social environments. However, modern perspectives no...
369
Cognitive Learning01:21

Cognitive Learning

1.1K
Cognitive learning is based on purposive behavior, incidental learning, and insight learning.
E. C. Tolman's theory of purposive behavior emphasizes that much behavior is goal-directed. He argued that to understand behavior, we must look at the entire sequence of actions leading to a goal. For instance, high school students study hard, not just due to past reinforcement but also to achieve the goal of getting into a good college.
Tolman introduced the idea that behavior is influenced by...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ginsenoside Rb2 modulates the skin barrier by targeting Src to regulate PI3K/Akt signaling in HaCaT cells.

Journal of ginseng research·2026
Same author

Efferocytosis enhances macrophage pro-angiogenic functions for bone marrow regeneration.

Cell death and differentiation·2026
Same author

Relationship between triglyceride-glucose-derived obesity indices and NAFLD in adolescents: A cross-sectional study.

Medicine·2026
Same author

Comparative efficacy of therapeutic modalities for metastatic uveal melanoma: a systemic review and network meta-analysis.

Frontiers in oncology·2026
Same author

Beyond the Gut: How the Thymus Reshapes the Immune Landscape of Inflammatory Bowel Disease.

Comprehensive Physiology·2026
Same author

Leukocyte concentrations of inpatients with anorexia nervosa.

Frontiers in psychiatry·2026
Same journal

LncRNA signature associated with amino acid metabolism: A novel prognostic tool for Clear Cell Renal Cell Carcinoma.

Current medicinal chemistry·2026
Same journal

HRI Kinase Modulation by BTdCPU as a Therapeutic Strategy for Bortezomib Resistance in Prostate Cancer.

Current medicinal chemistry·2026
Same journal

EGFR Dysregulation in Cancer: From Molecular Mechanisms and Key Mutations to Evolving TKI Strategies and Resistance Mitigation.

Current medicinal chemistry·2026
Same journal

DHRS2 as a Novel Thalidomide Target Regulating Mitophagy and Inflammation in Head and Neck Squamous Cell Carcinoma.

Current medicinal chemistry·2026
Same journal

Synthetic AtMP2 from Anabas testudineus: Comprehensive ADMET and In Vivo Toxicity Assessment to Enable Future Therapeutic Development.

Current medicinal chemistry·2026
Same journal

Screening of Medicinal and Edible Homology Substances for Diabetic Kidney Disease Based on GraphBAN.

Current medicinal chemistry·2026
See all related articles

Related Experiment Video

Updated: Jan 29, 2026

Author Spotlight: Improving Anesthesia Protocols for Enhanced Mouse Acupuncture Research
03:26

Author Spotlight: Improving Anesthesia Protocols for Enhanced Mouse Acupuncture Research

Published on: December 8, 2023

1.9K

Diabetic Cognitive Dysfunction: From Bench to Clinic.

Jiyin Zhou1, Zuo Zhang1, Hongli Zhou1

  • 1National Drug Clinical Trial Institution, the Second Affiliated Hospital, Army Medical University, Chongqing 400037, China.

Current Medicinal Chemistry
|February 8, 2019
PubMed
Summary
This summary is machine-generated.

Type 2 diabetes significantly elevates the risk of cognitive dysfunction in older adults, impacting memory and executive functions. Research highlights brain changes and various contributing factors, necessitating further investigation for better treatments.

Keywords:
Type 2 diabetescognitive dysfunctionhyperglycaemiainflammationinsulin resistancevascular disease.

More Related Videos

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats
07:41

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Published on: October 23, 2020

6.8K
A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
08:17

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

Published on: February 27, 2018

17.0K

Related Experiment Videos

Last Updated: Jan 29, 2026

Author Spotlight: Improving Anesthesia Protocols for Enhanced Mouse Acupuncture Research
03:26

Author Spotlight: Improving Anesthesia Protocols for Enhanced Mouse Acupuncture Research

Published on: December 8, 2023

1.9K
Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats
07:41

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Published on: October 23, 2020

6.8K
A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
08:17

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

Published on: February 27, 2018

17.0K

Area of Science:

  • Neuroscience
  • Endocrinology
  • Geriatrics

Background:

  • Type 2 diabetes is linked to cognitive dysfunction, particularly in the elderly, affecting short-term memory and executive functions.
  • Animal models of type 2 diabetes exhibit memory and learning deficits, supporting the association.
  • Key risk factors include vascular disease, metabolic abnormalities, insulin resistance, and genetic predispositions.

Purpose of the Study:

  • To summarize the current understanding of cognitive dysfunction in type 2 diabetes.
  • To outline the neuroimaging findings in diabetic patients with cognitive impairment.
  • To discuss the underlying pathogenesis and potential future research directions.

Main Methods:

  • Review of existing literature on type 2 diabetes and cognitive dysfunction.
  • Analysis of findings from genetic and diet-induced animal models.
  • Examination of neuroimaging studies in diabetic patients.

Main Results:

  • Diabetic cognitive dysfunction is associated with whole-brain atrophy, particularly in grey matter, hippocampus, and amygdala.
  • Neuroimaging reveals increased white matter and ventricular volume, brain infarcts, and impaired network integrity.
  • Pathogenesis involves hyperglycemia, vascular diseases, insulin resistance, inflammation, and neurotransmitter imbalances.

Conclusions:

  • Type 2 diabetes poses a significant risk for cognitive decline in the elderly.
  • Advanced neuroimaging and animal models are crucial for understanding pathogenesis and developing interventions.
  • Further clinical trials are needed to identify biomarkers and risk factors for effective treatment.