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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Cognitive therapy, pioneered by Aaron T. Beck in the 1960s, is a structured approach to addressing psychological distress by focusing on the influence of thoughts on emotions and behaviors. All cognitive therapies involve the basic assumption that human beings have control over their feelings, and that how individuals feel about something depends on how they think about it. Unlike psychoanalytic methods that delve into unconscious processes or humanistic approaches emphasizing...
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Related Experiment Video

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Isolation and Characterization of Microvesicles from Peripheral Blood
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Antithrombotic Therapy for Peripheral Revascularisation.

Marco De Carlo1, Marco Angelillis1, Riccardo Liga1

  • 1Cardiac Catheterization Laboratory, Cardiothoracic and Vascular Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.

Current Vascular Pharmacology
|February 8, 2019
PubMed
Summary
This summary is machine-generated.

Peripheral revascularization for lower extremity artery disease (LEAD) is increasing. Optimal antithrombotic therapy post-procedure needs more evidence, often extrapolated from coronary treatments.

Keywords:
Lower extremity artery diseaseanticoagulantsantiplateletsantithrombotic treatmentperipheral vascular interventionsvascular surgery.

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Area of Science:

  • Vascular Surgery
  • Cardiology
  • Pharmacology

Background:

  • Lower extremity artery disease (LEAD) is a significant global health issue.
  • Peripheral vascular interventions (PVI) for LEAD are rising due to improved endovascular techniques.
  • Optimal antithrombotic strategies post-PVI are not well-established.

Purpose of the Study:

  • To review indications and techniques for endovascular and surgical revascularization in LEAD.
  • To analyze current evidence on antiplatelet and anticoagulant therapy after PVI.
  • To highlight the need for optimized antithrombotic approaches in PVI.

Main Methods:

  • Literature review of peripheral revascularization techniques.
  • Analysis of clinical trial data on antithrombotic treatments post-PVI.
  • Comparison of LEAD antithrombotic strategies with coronary interventions.

Main Results:

  • PVI rates have increased significantly worldwide.
  • Current antithrombotic guidelines for PVI are largely based on coronary data.
  • Evidence for optimal antiplatelet and anticoagulant use in PVI is limited.

Conclusions:

  • Further research is needed to define optimal antithrombotic regimens for PVI.
  • Tailored antithrombotic strategies are crucial given the extensive disease treated in PVI.
  • Current practices often extrapolate from coronary interventions, necessitating LEAD-specific evidence.