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Efficacy of a 14-day course of amoxicillin for patients with erythema migrans

Gary P Wormser1, Kathryn C Brady1, Michelle S Cho1

  • 1Division of Infectious Diseases, New York Medical College, Valhalla, NY 10595.

Diagnostic Microbiology and Infectious Disease
|February 8, 2019
PubMed

Insights

A 14-day course of amoxicillin effectively treats early Lyme disease. This antibiotic regimen was well-tolerated and prevented serious complications in adult patients with erythema migrans.

Area of Science:

  • Infectious Diseases
  • Dermatology
  • Clinical Medicine

Background:

  • Amoxicillin is widely used for early Lyme disease, but evidence supporting its efficacy and safety is limited, especially in the United States.
  • Erythema migrans is the characteristic skin lesion of early Lyme disease.

Purpose of the Study:

  • To evaluate the efficacy and safety of a 14-day amoxicillin treatment course for early Lyme disease in adult patients.
  • To assess the resolution of erythema migrans and prevention of disseminated manifestations.

Main Methods:

  • Prospective review of medical records of 24 adult patients with erythema migrans.
  • Patients received a 14-day course of amoxicillin, 500 mg three times daily.

Main Results:

  • Amoxicillin treatment was well-tolerated by all patients.
  • The treatment uniformly resolved the erythema migrans skin lesions.
  • No objective neurologic, cardiac, or rheumatologic manifestations developed in treated patients.

Conclusions:

  • A 14-day course of amoxicillin (500 mg TID) is highly effective for treating early Lyme disease.
  • This regimen demonstrates good safety and efficacy in preventing disseminated Lyme disease manifestations.
Keywords:
AmoxicillinBorrelia burgdorferiLyme diseaseTreatment

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