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Spontaneous diabetes in eSS rats.

S M Martínez1, M C Tarrés, S Montenegro

  • 1Facultad de Ciencias Médicas, Consejo de Investigaciones de la Universidad Nacional de Rosario, Argentina.

Acta Diabetologica Latina
|October 1, 1988
PubMed
Summary

A novel rat model of non-insulin-dependent diabetes (eSS) exhibits impaired glucose tolerance and metabolic disturbances. Diabetic eSS rats showed pancreatic changes and kidney disease, with some improvement seen during food deprivation.

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Area of Science:

  • Endocrinology
  • Diabetology
  • Animal Models

Background:

  • A spontaneous non-insulin-dependent diabetes model, eSS rats, displays progressive glucose intolerance.
  • Males are disproportionately affected, exhibiting hypertriglyceridemia and hypercholesterolemia.

Purpose of the Study:

  • To characterize the metabolic and histopathological features of the eSS rat model of diabetes.
  • To investigate the effects of age and food deprivation on metabolic disturbances in eSS rats.

Main Methods:

  • Assessment of glucose tolerance, plasma insulin, triglycerides, and cholesterol levels.
  • Histopathological examination of pancreatic islets and kidney tissues.
  • Evaluation of metabolic parameters under long-term food deprivation.

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Main Results:

  • eSS rats showed impaired glucose tolerance, hypertriglyceridemia, and hypercholesterolemia.
  • Despite hyperglycemia, eSS males had elevated plasma insulin, indicating insulin sensitivity.
  • Pancreatic islet disruption and kidney pathology (glomerulosclerosis, nephrosis) were observed, worsening with age.
  • Long-term food deprivation improved metabolic disturbances in diabetic eSS males.

Conclusions:

  • The eSS rat is a valuable model for studying non-insulin-dependent diabetes, particularly its progressive nature and associated metabolic complications.
  • Age-related decline in insulin levels exacerbates glucose intolerance in this model.
  • The observed pancreatic and renal pathologies highlight the systemic impact of diabetes in eSS rats.