Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Cell Cycle Control System01:28

The Cell Cycle Control System

5.6K
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
5.6K
The Cell Cycle Control System02:11

The Cell Cycle Control System

14.3K
The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
14.3K
Fates of Pyruvate01:20

Fates of Pyruvate

10.7K
Pyruvate is the end product of glycolysis, where glucose is oxidized to pyruvate, simultaneously reducing NAD+ to NADH. Two molecules of ATP are also produced by substrate-level phosphorylation.
In aerobic organisms, pyruvate is metabolized via the citric acid cycle to produce reduced coenzymes NADH and FADH2. These coenzymes are then oxidized in the electron transport chain to produce ATP and, in the process, regenerate the NAD+ and FAD. As seen in some cell types and organisms, fermentation...
10.7K
Understanding the Self01:28

Understanding the Self

283
The self is a central aspect of human identity, encompassing an individual’s beliefs, emotions, perceptions, and experiences. It is a cognitive and psychological construct that enables individuals to interpret their traits and behaviors, influencing how they perceive themselves and interact with the world. While personality consists of stable and enduring characteristics, the self is shaped by self-perception and social experiences. This distinction highlights the dynamic nature of the...
283
Understanding Self-Concept01:20

Understanding Self-Concept

272
The self-concept encompasses individuals' beliefs about themselves, structured through cognitive frameworks known as self-schemas. These schemas function as mental representations of specific traits or behaviors, influencing how self-relevant information is perceived, processed, and remembered. For example, individuals who are schematic for body weight are more likely to interpret routine experiences—such as dining out or shopping—through the lens of that trait. Conversely, those...
272
Understanding Deception01:14

Understanding Deception

166
Deception is a pervasive aspect of human communication. Empirical studies have shown that most individuals engage in some form of deceit on a daily basis, with approximately 20% of social exchanges involving deceptive elements. Lying follows a developmental trajectory, peaking during adolescence and declining with age, possibly due to the maturation of cognitive control and social accountability.Cognitive and Social Factors in Deception DetectionDespite its prevalence, accurately detecting...
166

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Bispecific Anti-Fluorescein × Anti-CD3 T-cell Engager in Combination with Fluoresceinated Adaptors Enables Lysis of AML Cells.

Molecular cancer therapeutics·2026
Same author

Enhancement of CD117-Targeted Bispecific T-cell Engagement by CD33-Targeted Bispecific T-cell Costimulation in Acute Myeloid Leukemia.

Cancer research communications·2026
Same author

A bispecific anti-fluorescein x anti-CD3 T-cell engager in combination with fluoresceinated adaptors enables lysis of AML cells.

Molecular cancer therapeutics·2026
Same author

Elevated endocytic trafficking mediated by GPRASP2 maintains HSC fidelity.

bioRxiv : the preprint server for biology·2026
Same author

Cell polarity: cell type-specific regulators, common pathways, and polarized vesicle transport.

Leukemia·2025
Same author

Senolytics restore hematopoietic stem cell function in sickle cell disease.

bioRxiv : the preprint server for biology·2025
Same journal

Fibrocytes drive JAK2V617F-mutated myelofibrosis: pitavastatin reverses marrow fibrosis and anemia.

Blood·2026
Same journal

Identifying steroid-refractory aGVHD before it happens.

Blood·2026
Same journal

ELISA-negative HIT: antibody recognition and relevance.

Blood·2026
Same journal

EBV and immunodeficiency: the odd couple drawn to the brain.

Blood·2026
Same journal

A bone to pick with ferric carboxymaltose.

Blood·2026
Same journal

A step toward streamlining HIT diagnosis.

Blood·2026
See all related articles

Related Experiment Video

Updated: Jan 29, 2026

Single Cell Fate Mapping in Zebrafish
07:53

Single Cell Fate Mapping in Zebrafish

Published on: October 5, 2011

13.9K

Understanding cell fate control by continuous single-cell quantification.

Dirk Loeffler1, Timm Schroeder1

  • 1Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule Zurich, Basel, Switzerland.

Blood
|February 8, 2019
PubMed
Summary
This summary is machine-generated.

Quantitative single-cell imaging offers a powerful method to observe dynamic molecular processes in hematopoietic cells. This technique helps resolve long-standing biological questions and can lead to new therapeutic strategies for diseases.

More Related Videos

Following Cell-fate in E. coli After Infection by Phage Lambda
06:10

Following Cell-fate in E. coli After Infection by Phage Lambda

Published on: October 14, 2011

24.2K
Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel
08:29

Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel

Published on: May 14, 2018

10.5K

Related Experiment Videos

Last Updated: Jan 29, 2026

Single Cell Fate Mapping in Zebrafish
07:53

Single Cell Fate Mapping in Zebrafish

Published on: October 5, 2011

13.9K
Following Cell-fate in E. coli After Infection by Phage Lambda
06:10

Following Cell-fate in E. coli After Infection by Phage Lambda

Published on: October 14, 2011

24.2K
Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel
08:29

Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel

Published on: May 14, 2018

10.5K

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Hematopoiesis

Background:

  • Cellular and molecular processes are highly dynamic, necessitating advanced observation methods.
  • Traditional population-based or snapshot analyses fail to capture the full picture of cellular dynamics.
  • In vivo long-term single-cell studies face technical limitations, making in vitro methods crucial.

Purpose of the Study:

  • To review the application of continuous quantitative single-cell imaging in hematopoiesis research.
  • To highlight how this technique resolves long-standing controversies in cell fate decisions.
  • To underscore the potential of single-cell imaging for understanding disease mechanisms and developing therapies.

Main Methods:

  • Long-term in vitro single-cell imaging and tracking.
  • Quantitative analysis of dynamic molecular processes.
  • Focus on hematopoietic cell populations, including rare and heterogeneous groups.

Main Results:

  • Demonstrated success in resolving decades-long controversies in hematopoietic cell behavior.
  • Provided insights into dynamic molecular mechanisms previously unobservable.
  • Established the value of in vitro single-cell imaging for studying complex biological questions.

Conclusions:

  • Continuous quantitative single-cell imaging is a vital tool for understanding dynamic biological processes.
  • Aberrant cell fate decisions in diseases can be better understood through molecular dynamics.
  • This approach promises to advance therapeutic strategies for various degenerative diseases and conditions.