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Updated: Jan 29, 2026

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p53 induces senescence through Lamin A/C stabilization-mediated nuclear deformation

Min-Ho Yoon1, So-Mi Kang1, Su-Jin Lee1

  • 1Department of Molecular Biology, College of Natural Science, Pusan National University, Busan, 46241, Republic of Korea.

Cell Death & Disease
|February 8, 2019
PubMed
Summary

The tumor suppressor p53 stabilizes Lamin A/C, which reduces BMI-1/MEL-18 and induces p16/INK4A expression, promoting cellular senescence. This p53-Lamin A/C network is crucial for p16-mediated senescence.

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