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Intravitreal Injections in the Ovine Eye
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Intravitreal aflibercept for active polypoidal choroidal vasculopathy without active polyps.
Sang Eun Lee1, Jun Won Jang1, Se Woong Kang2
1Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Scientific Reports
|February 8, 2019
Summary
Intravitreal aflibercept improved vision in patients with polypoidal choroidal vasculopathy (PCV) without active polyps. Good baseline vision and absence of inner retinal cysts predict better outcomes.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Medical Imaging
Background:
- Polypoidal choroidal vasculopathy (PCV) is a subtype of age-related macular degeneration.
- PCV can lead to exudation and vision loss.
- Prior treatments like photodynamic therapy (PDT) and anti-VEGF agents may not fully resolve PCV.
Purpose of the Study:
- To assess the efficacy of intravitreal aflibercept in patients with PCV exhibiting exudation but not active polyps.
- To identify prognostic factors for visual outcomes in this patient group.
- To evaluate aflibercept's effectiveness after previous treatments.
Main Methods:
- A study of 40 eyes with PCV and exudation, previously treated with PDT and/or other anti-VEGF therapies.
- Intravitreal aflibercept injections administered monthly for three months, followed by bi-monthly injections.
- Assessment of spectral-domain optical coherence tomography and indocyanine green angiography features.
Main Results:
- Mean visual acuity improved significantly from 61.5 to 68.1 letters at 14 months (P=0.001).
- Better baseline vision and smaller branching vascular networks correlated with improved final visual acuity.
- Presence of inner retinal cysts at 1 month post-induction therapy was linked to worse visual outcomes (P=0.011).
Conclusions:
- Intravitreal aflibercept offers significant visual and anatomical benefits for PCV with exudation, even after prior treatments.
- Prognostic factors for favorable outcomes include better initial vision, smaller lesion size, and absence of inner retinal cysts post-induction therapy.
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