Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

9.9K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.9K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.6K
3.6K
RNA Splicing01:32

RNA Splicing

60.6K
Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
60.6K
Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

14.8K
Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
14.8K
Nursing Code of Ethics01:29

Nursing Code of Ethics

4.5K
The Nursing Code of Ethics sets the ethical benchmark for the profession, and guides nurses in ethical analysis and decision making at the societal, organizational, and clinical levels. The code encompasses showing compassion and respect for the patient, their families, and communities in all circumstances while committing to providing patient-centered care. In addition, the code states that nurses must advocate for the patient by defending a cause or recommendation to protect their rights,...
4.5K
Transfer RNA Synthesis02:36

Transfer RNA Synthesis

13.3K
One of the unique features of tRNA is the presence of modified bases. In some tRNAs, modified bases account for nearly 20% of the total bases in the molecule. Altogether, these unusual bases protect the tRNA from enzymatic degradation by RNases.
Each of these chemical modifications is carried by a specific enzyme, post-transcription. All of these enzymes have unique base and site-specificity. Methylation, the most common chemical modification, is carried by at least nine different enzymes, with...
13.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Model establishment of liver fibrosis in oral arsenic solution exposed mice].

Zhonghua yi xue za zhi·2009
Same author

Effect of human cytomegalovirus infection on nerve growth factor expression in human glioma U251 cells.

Biomedical and environmental sciences : BES·2009
Same author

[Study on the mechanism of arsenic trioxide inhibiting NB4 cells proliferation].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·2009
Same author

Reversal of P-glycoprotein-mediated multidrug resistance by guggulsterone in doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells.

Die Pharmazie·2009
Same author

Structures of discoidal high density lipoproteins: a combined computational-experimental approach.

The Journal of biological chemistry·2009
Same author

Dynamic regulation of GSH synthesis and uptake pathways in the rat lens epithelium.

Experimental eye research·2009

Related Experiment Video

Updated: Jan 29, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

26.3K

Long Non-coding RNA in Neuronal Development and Neurological Disorders.

Ling Li1,2, Yingliang Zhuang1,2, Xingsen Zhao1,2

  • 1The Children's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Frontiers in Genetics
|February 8, 2019
PubMed
Summary

Long non-coding RNAs (lncRNAs), non-protein-coding transcripts, regulate crucial biological processes. Their dysregulation is linked to neurological disorders, highlighting their importance in neuronal development and disease.

Keywords:
gene expressionlong non-coding RNAmechanismneurological disordersneuronal development

More Related Videos

Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood
09:40

Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood

Published on: November 28, 2018

7.8K
Isolation of High-density Lipoproteins for Non-coding Small RNA Quantification
10:39

Isolation of High-density Lipoproteins for Non-coding Small RNA Quantification

Published on: November 28, 2016

11.8K

Related Experiment Videos

Last Updated: Jan 29, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

26.3K
Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood
09:40

Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood

Published on: November 28, 2018

7.8K
Isolation of High-density Lipoproteins for Non-coding Small RNA Quantification
10:39

Isolation of High-density Lipoproteins for Non-coding Small RNA Quantification

Published on: November 28, 2016

11.8K

Area of Science:

  • Molecular Biology
  • Genetics
  • Neuroscience

Background:

  • Long non-coding RNAs (lncRNAs) are RNA molecules longer than 200 nucleotides without protein-coding potential.
  • LncRNAs play vital roles in gene regulation, influencing processes like RNA processing, cell fate, and development.
  • Aberrant lncRNA expression is implicated in various human diseases, particularly neurological disorders.

Purpose of the Study:

  • To review recent advancements in understanding lncRNA functions and molecular mechanisms.
  • To focus on the role of lncRNAs in neuronal development.
  • To explore the involvement of lncRNAs in neurological disorders.

Main Methods:

  • Literature review of recent research on lncRNAs.
  • Analysis of molecular mechanisms underlying lncRNA function.
  • Synthesis of findings related to neuronal development and neurological diseases.

Main Results:

  • LncRNAs are key regulators in diverse biological pathways.
  • Specific lncRNAs are critical for normal neuronal development.
  • Dysfunctional lncRNAs contribute to the pathogenesis of neurological disorders.

Conclusions:

  • LncRNAs represent a significant area of study in molecular biology and neuroscience.
  • Further research into lncRNA function and mechanisms is crucial for understanding and treating neurological disorders.