Related Experiment Video

Updated: Jan 29, 2026

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.5K

Disrupted Regional Spontaneous Neural Activity in Mild Cognitive Impairment Patients with Depressive Symptoms: A

Xiaozheng Liu1, Yunhai Tu2, Yirou Zang1

  • 1China-USA Neuroimaging Research Institute, Department of Radiology of the Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.

Neural Plasticity
|February 8, 2019
PubMed

Insights

Depression in mild cognitive impairment (MCI) alters brain activity patterns. Depressed MCI patients show distinct coherence regional homogeneity (CReHo) in key brain regions, suggesting sensorimotor network involvement.

Area of Science:

  • Neuroimaging
  • Cognitive Neuroscience
  • Psychiatry

Background:

  • Depressive symptoms are prevalent in mild cognitive impairment (MCI), increasing dementia risk.
  • Brain activity patterns in MCI patients with depression remain poorly understood.
  • Resting-state functional magnetic resonance imaging (rsfMRI) offers insights into spontaneous brain activity.

Purpose of the Study:

  • To investigate differences in spontaneous brain activity between MCI patients with and without depressive symptoms.
  • To analyze coherence regional homogeneity (CReHo) in specific frequency bands using rsfMRI.
  • To explore correlations between CReHo and clinical variables in depressed MCI patients.

Main Methods:

  • Acquired rsfMRI data from 16 depressed MCI (D-MCI) and 18 non-depressed MCI (nD-MCI) patients.
  • Utilized coherence regional homogeneity (CReHo) analysis across typical, slow-4, and slow-5 frequency bands.
  • Performed statistical and correlation analyses between CReHo values and clinical measures (e.g., HAMD scores).

Main Results:

  • D-MCI patients showed higher CReHo in the left Heschl's gyrus and left thalamus (typical and slow-4 bands).
  • Lower CReHo was observed in the left postcentral gyrus (typical band) and superior medial prefrontal gyrus (slow-5 band) in D-MCI patients.
  • Left thalamus CReHo positively correlated with Hamilton Depression Rating Scale (HAMD) scores in D-MCI patients.

Conclusions:

  • Spontaneous brain activity patterns differ significantly between D-MCI and nD-MCI patients.
  • The sensorimotor network is implicated as a key pathophysiological factor in D-MCI.
  • CReHo analysis provides valuable biomarkers for understanding D-MCI and its relationship with depressive symptoms.

More Related Videos

Digital Handwriting Analysis of Characters in Chinese Patients with Mild Cognitive Impairment05:58

Digital Handwriting Analysis of Characters in Chinese Patients with Mild Cognitive Impairment

Published on: March 11, 2021

5.1K
A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

8.1K

Related Concept Videos

Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
546
Spontaneity02:21

Spontaneity

A spontaneous process is one that occurs naturally under certain conditions. A nonspontaneous process, on the other hand, will not take place unless it is “driven” by the continual input of energy from an external source. Processes have a natural tendency to occur in one direction under a given set of conditions. Water will naturally flow downhill (spontaneous process), but uphill flow (nonspontaneous process) requires outside intervention such as the use of a pump. Iron exposed to...
29.8K
Cognitive Dissonance01:38

Cognitive Dissonance

Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
37.5K
The Resting Membrane Potential01:21

The Resting Membrane Potential

Overview
142.3K
Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.3K
Freezing Point Depression and Boiling Point Elevation03:12

Freezing Point Depression and Boiling Point Elevation

Boiling Point Elevation
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
40.0K