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Lectins in cancer cells.

R Lotan1, A Raz

  • 1Department of Tumor Biology, University of Texas, M.D. Anderson Cancer Center, Houston 77030.

Annals of the New York Academy of Sciences
|January 1, 1988
PubMed
Summary
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Tumor cells express surface lectins, which are carbohydrate-binding proteins, at varying levels. Increased lectin expression correlates with higher metastatic potential and transformation, suggesting roles in cell adhesion and metastasis.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Oncology

Background:

  • Tumor cells and normal cells share similar lectins in sugar-binding specificity, molecular size, and antigenicity.
  • Lectins from tumor cells exhibit sequence homology with those from normal tissues.

Purpose of the Study:

  • To investigate the presence and role of lectins on the surface of tumor cells.
  • To determine the correlation between lectin levels and tumor cell characteristics like metastatic potential and transformation.
  • To explore the involvement of tumor cell lectins in cellular interactions and tumor progression.

Main Methods:

  • Purification of lectins from various tumor cells using affinity chromatography.
  • Preparation of monoclonal and polyclonal antilectin antibodies.

Related Experiment Videos

  • Analysis of lectin levels on tumor cell surfaces and their correlation with oncogene/retrovirus transformation and metastatic propensity.

    • Main Results:

    • Lectins are present on the surface of all examined tumor cells, with levels increasing after transformation.
    • Higher metastatic potential in tumor cells correlates with higher surface lectin expression.
    • Tumor cell lectins may be involved in cell-cell adhesion, attachment, anchorage-independent growth, and metastasis.

    Conclusions:

    • Tumor cell surface lectins are implicated in cellular interactions, growth, malignant transformation, differentiation, and metastasis.
    • Altered expression of cell surface lectins during transformation affects cellular interactions.
    • Further research is crucial to elucidate the functions and regulatory mechanisms of tumor lectins in cancer progression.