Related Experiment Video
Updated: Jan 29, 2026
09:02
Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
22.4K
Chronic Lymphocytic Leukemia Presenting as a Subcortical Watershed Infarct
Mridul Gupta1, Divita Singh2, Patrick Lee3
1Internal Medicine, Monmouth Medical Center, Long Branch, New Jersey, USA.
Case Reports in Hematology
|February 8, 2019
Summary
This study reports an extremely rare case of watershed infarcts caused by autoimmune hemolytic anemia secondary to chronic lymphocytic leukemia. This highlights a novel, albeit rare, presentation of CLL complications.
Area of Science:
- Neurology
- Hematology
- Oncology
Background:
- Internal watershed infarcts (WI) typically result from low blood flow or microembolism affecting the middle cerebral artery's white matter.
- Anemia is a rare cause of WI, with even fewer documented cases of hemolytic anemia leading to cerebral infarcts.
Observation:
- Chronic lymphocytic leukemia (CLL) often presents with secondary autoimmune cytopenias, including autoimmune hemolytic anemia (AIHA).
- AIHA occurs in 7-10% of CLL patients.
Findings:
- This case details an extremely rare instance of AIHA secondary to CLL presenting as internal watershed infarcts.
- To our knowledge, this is the first reported case of CLL-induced AIHA manifesting as WI.
Implications:
- This case expands the spectrum of neurological complications associated with CLL.
- It underscores the importance of considering hematological causes, particularly AIHA in CLL patients, when evaluating unexplained watershed infarcts.
More Related Videos
Related Concept Videos
01:23Chronic Pharyngitis
11.8K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
11.8K
01:24Chronic Pancreatitis I: Introduction
728
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
728
01:17Chronic Bowel Disorders: Introduction
795
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
795
01:29Chronic Pancreatitis II: Collaborative Care
362
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
362
01:25Chronic Kidney Disease I: Introduction
725
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
725
01:24Chronic Obstructive Pulmonary Disease
2.5K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
2.5K