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Exploring metabolic and inflammatory abnormalities in rheumatoid arthritis patients developing stroke disease: a
Fangran Xin1, Lingyu Fu2,3, Haina Liu4
1Department of Clinical Epidemiology and Evidence-based medicine, The First Affiliated Hospital of China Medical University, No.155, Nan Jing Bei Street, Shenyang, 110001, Liaoning Province, China.
Insights
Rheumatoid arthritis (RA) patients with high levels of erythrocyte sedimentation rate (ESR), low-density lipoprotein cholesterol (LDL-C), and C-reactive protein (CRP) face increased stroke risk. Monitoring these markers is crucial for stroke prevention in RA.
Area of Science:
- Cardiovascular Medicine
- Rheumatology
- Neurology
Background:
- Rheumatoid arthritis (RA) is a chronic inflammatory disease.
- Stroke is a significant comorbidity in RA patients.
- Understanding risk factors for stroke in RA is critical for prevention.
Purpose of the Study:
- To investigate the association between serum lipids, inflammatory markers, and serological status with stroke risk in RA patients.
- To identify specific biomarkers predicting stroke in this population.
Main Methods:
- A case-control study utilizing electronic medical records from January 2011 to March 2018.
- 1057 study subjects categorized into case and control groups (1:2 ratio), matched for age and gender.
- Multinomial logistic regression and restricted cubic spline analyses were employed.
Main Results:
- Elevated erythrocyte sedimentation rate (ESR), low-density lipoprotein cholesterol (LDL-C), and C-reactive protein (CRP) ≥ 230 mg/L were independent risk factors for stroke in RA patients.
- ESR and LDL-C showed a linear association with stroke risk.
- CRP exhibited a non-linear association with stroke risk.
Conclusions:
- RA patients with dyslipidemia and elevated inflammatory markers require close monitoring for stroke risk.
- Primary stroke prevention strategies should target these identified risk factors in RA patients.
Objectives:
Intend to investigate the roles of serum lipids, inflammatory markers, and serological status in rheumatoid arthritis and stroke patients by using case-control study.
Materials And Methods:
Clinical data were retrieved from the electronic medical record of the First Affiliated Hospital of China Medical University during January 2011 to March 2018. The obtained data were categorized into case groups and three control groups, in the ratios of 1:2, respectively, with all matching age and gender. Multinomial logistic regression analysis and restricted cubic spline were conducted examining the associations between serum lipids, inflammatory markers, serological status, and the risk of stroke among RA patients.
Results:
The present studies included 1057 study subjects. The elevated ESR, LDL-C levels, and much higher CRP levels ≥ 230 mg/L were independent risk factors for RA patients in developing stroke. Furthermore, we found that ESR and LDL-C levels could exhibit a linear association with the risk of comorbid stroke while CRP level had a nonlinearity association with stroke risk among RA patients.
Conclusions:
A close monitoring is required for RA patients with dyslipidemia and elevated inflammatory markers, and the primary stroke preventive strategies should be directed against these risk factors.
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