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KIBRA polymorphism modulates gray matter volume to influence cognitive ability in the elderly
Rui Li1,2, Wenyu Wan1,2, Juan Li3,4,5,6
1Center on Aging Psychology, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang District, Beijing, 100101, China.
Brain Imaging and Behavior
|February 8, 2019
Summary
Genetic variation in the kidney and brain expressed protein (KIBRA) rs17070145 influences brain structure and cognitive aging. Lower gray matter volume in specific brain regions was observed in C-allele carriers, impacting cognitive function in the elderly.
Area of Science:
- Neuroscience
- Genetics
- Cognitive Aging
Background:
- Genetic variations in the KIBRA gene are linked to episodic memory and cognitive aging.
- The precise neural mechanisms remain unclear.
Purpose of the Study:
- To investigate the impact of KIBRA rs17070145 polymorphism on gray matter volume in older adults.
- To explore the neural underpinnings of KIBRA's influence on cognitive function.
Main Methods:
- Magnetic resonance imaging (MRI) was used to assess gray matter volume.
- Voxel-based morphometry (VBM) and multi-voxel pattern correlation analyses were performed.
- 37 healthy older Chinese adults participated in the study.
Main Results:
- KIBRA polymorphism significantly affects gray matter volume in the prefrontal and parahippocampal cortex.
- C-allele carriers exhibited lower gray matter volume in these regions compared to TT carriers.
- Decreased prefrontal gray matter volume correlated with cognitive function in C-allele carriers, while TT carriers showed more integrated whole-brain gray matter utilization.
Conclusions:
- The KIBRA rs17070145 polymorphism modulates gray matter volume in key brain regions.
- This modulation of gray matter volume influences cognitive function in the elderly population.
- Findings provide insights into the genetic basis of cognitive aging and memory.
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