Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

6.4K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
6.4K
Bone Structure01:55

Bone Structure

51.7K
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
51.7K
Bone Remodeling01:40

Bone Remodeling

40.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.4K
Compact Bone01:27

Compact Bone

16.4K
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
16.4K
Bone Disorders01:29

Bone Disorders

5.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.4K
The Hyoid Bone01:12

The Hyoid Bone

5.0K
The hyoid bone is a small U-shaped bone located in the upper neck at the level of the inferior mandible, with its tips pointing posteriorly. It does not directly articulate with any other bone in the body. The hyoid acts as the attachment site for the tongue, the larynx, and the pharynx. It is held in position by a series of small muscles attached from above or below. These muscles help to move the hyoid up/down or forward/back in coordination with movements of the tongue, larynx, and pharynx...
5.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In Vitro Effects of the Three Actives IL-12 (5 CH), IFN-γ (6 CH), and TNF-α (5 CH) from the Micro-Immunotherapy Medicine 2LEID-N<sup>®</sup> on Several Populations of Immune Cells.

Current issues in molecular biology·2026
Same author

Perspective: Personalized Management of Oxidative and Nitrosative Stress in Post-Exercise Recovery with a Particular Emphasis on the Potential of Micro-Immunotherapy.

Sports (Basel, Switzerland)·2026
Same author

Tetraploidy in cancer: Diagnostic and therapeutic perspectives.

Biochemical pharmacology·2026
Same author

Sphingosine-1-Phosphate Promotes FOS Activation in Osteosarcoma Under Tumor Acidosis.

Acta physiologica (Oxford, England)·2026
Same author

Mechanical confinement balances ECM remodeling in chondrocytes via MAPK and Hedgehog signaling.

Biomaterials·2026
Same author

Factor VIII restores bone parameters and modulates muscle proteo-metabolome in Factor VIII knockout male mice.

Bone research·2026

Related Experiment Video

Updated: Jan 29, 2026

The In ovo CAM-assay as a Xenograft Model for Sarcoma
12:44

The In ovo CAM-assay as a Xenograft Model for Sarcoma

Published on: July 17, 2013

26.3K

Murine Models of Bone Sarcomas.

Camille Jacques1, Nathalie Renema2, Benjamin Ory1

  • 1INSERM, UMR1238, Bone Sarcoma and Remodeling of Calcified Tissues, Université de Nantes, Nantes Atlantique Universités, Nantes, France.

Methods in Molecular Biology (Clifton, N.J.)
|February 8, 2019
PubMed
Summary
This summary is machine-generated.

This chapter details methods for inducing bone sarcoma in mice using two inoculation models. Procedures cover cell preparation, anesthesia, surgical techniques, and post-operative care for bone cancer research.

Keywords:
Bone sarcomaCell-injectionChondrosarcomaEwing sarcomaGenetically-engineered mouse modelsMurine preclinical modelsOsteosarcoma

More Related Videos

An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus
09:53

An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus

Published on: August 25, 2017

9.3K
Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

43.1K

Related Experiment Videos

Last Updated: Jan 29, 2026

The In ovo CAM-assay as a Xenograft Model for Sarcoma
12:44

The In ovo CAM-assay as a Xenograft Model for Sarcoma

Published on: July 17, 2013

26.3K
An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus
09:53

An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus

Published on: August 25, 2017

9.3K
Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

43.1K

Area of Science:

  • Oncology
  • Surgical Pathology
  • Animal Models

Background:

  • Bone sarcoma is a rare but aggressive cancer.
  • Developing reliable animal models is crucial for understanding sarcoma development and testing therapies.
  • Existing models may not fully recapitulate the complexity of human bone cancers.

Purpose of the Study:

  • To describe standardized procedures for inducing bone sarcoma in mice.
  • To present two distinct models for paraosseous and intraosseous inoculation.
  • To provide comprehensive guidance on surgical and post-operative management.

Main Methods:

  • Detailed description of cell preparation techniques for inoculation.
  • Explanation of anesthesia protocols and surgical approaches for paraosseous and intraosseous tumor induction.
  • Guidelines for post-operative monitoring and care of mice.

Main Results:

  • Successful induction of bone sarcoma in mice using the described methods.
  • Demonstration of two viable models for studying paraosseous and intraosseous bone cancers.
  • Establishment of a reproducible protocol for sarcoma induction and management.

Conclusions:

  • The described procedures provide a robust framework for generating mouse models of bone sarcoma.
  • These models facilitate research into the pathogenesis and treatment of bone cancers.
  • Standardized protocols enhance reproducibility and comparability in sarcoma research.