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Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
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Related Experiment Video

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Activation of Apoptosis by Cytoplasmic Microinjection of Cytochrome c
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Techniques for the Study of Apoptosis in Bone.

Val Mann1, Brendon Noble2

  • 1Faculty of Medicine and Dentistry, University of Plymouth, Plymouth, UK.

Methods in Molecular Biology (Clifton, N.J.)
|February 8, 2019
PubMed
Summary

Osteocyte apoptosis, programmed cell death in bone cells, is linked to bone disease. This study details methods for detecting apoptosis in bone, aiding research into bone metabolism and structural integrity.

Keywords:
ApoptosisBoneCaspaseNick translationOsteocyte

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Area of Science:

  • Bone biology
  • Cellular biology
  • Pathology

Background:

  • Osteocyte apoptosis is implicated in various bone conditions and targeted bone remodeling.
  • Understanding apoptosis regulation in bone is crucial for bone metabolism and disease research.
  • The biological role of osteocyte apoptosis in bone structural integrity is of significant interest.

Purpose of the Study:

  • To describe methods for detecting apoptosis in bone.
  • To facilitate the study of apoptosis regulation in bone.
  • To investigate the role of apoptosis in bone health and disease.

Main Methods:

  • Detection of apoptosis in bone sections.
  • Detection of apoptosis in bone cell cultures.
  • Methodological descriptions for apoptosis assessment in bone.

Main Results:

  • Established methods for apoptosis detection in bone samples.
  • Provided protocols for assessing osteocyte apoptosis in vitro and in situ.
  • Enabled further research into the mechanisms and consequences of bone cell apoptosis.

Conclusions:

  • The described methods are valuable tools for studying osteocyte apoptosis.
  • Accurate detection of apoptosis is essential for understanding bone disease.
  • Further research into apoptosis mechanisms will advance bone therapeutics.