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Changes in minimum hemoglobin and interdonation interval: impact on donor hemoglobin and donation frequency.
Mindy Goldman1, Qi-Long Yi1, Tony Steed2
1Donor & Clinical Services, Canadian Blood Services, Ottawa, Ontario, Canada.
Transfusion
|February 8, 2019
Summary
New blood donation policies reduced iron deficiency in female donors by increasing donation intervals and raising hemoglobin cutoffs for males. These changes improved hemoglobin levels and decreased deferrals, particularly for women, while slightly increasing deferrals for men.
Area of Science:
- Hematology
- Transfusion Medicine
- Public Health
Background:
- Donor iron deficiency is a significant concern in whole blood donation.
- Previous strategies focused on iron supplementation and dietary advice.
- Intervention aimed to optimize donation parameters to mitigate donor iron depletion.
Purpose of the Study:
- To evaluate the impact of modified hemoglobin (Hb) cutoffs and interdonation intervals on blood donors.
- To assess changes in Hb levels, deferral rates, and donor base characteristics.
- To mitigate donor iron deficiency in the context of whole blood donation.
Main Methods:
- Modified the minimum Hb cutoff for males from 125 g/L to 130 g/L in March 2017.
- Increased the interdonation interval for females from 56 to 84 days starting in March 2017.
- Analyzed Hb levels, deferral rates, donation frequency, and donor base size pre- and post-intervention.
Main Results:
- Female Hb deferral rates decreased from 13.0% to 9.5%; male rates increased from 1.2% to 2.1%; overall rates decreased from 6.8% to 5.4%.
- Mean Hb increased in both females (135.0 to 136.2 g/L) and males (149.9 to 150.6 g/L).
- Presentations with Hb below 120 g/L decreased by 27%; annual donation frequency dropped by 12% in females and 4% in males; donor base expanded by 5.8%.
Conclusions:
- The implemented changes positively impacted female donors, improving Hb distribution and reducing deferrals.
- Male donors experienced a slight increase in mean Hb but also higher deferral rates.
- The study highlights the complex relationship between donation frequency, donor base composition, and intervention effectiveness in managing donor iron status.
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