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Related Experiment Video

Updated: Jan 29, 2026

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model
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The Pros1/Tyro3 axis protects against periodontitis by modulating STAT/SOCS signalling.

Lei Jiang1, Xiao Qing Chen1, Ming Jing Gao1

  • 1Department of Stomatology, Changzheng Hospital, Second Military Medical University, Shanghai, P. R. China.

Journal of Cellular and Molecular Medicine
|February 8, 2019
PubMed
Summary

Pros1, a protein involved in inflammation resolution, shows promise as a novel therapy for periodontitis. Administering Pros1 reduced inflammation and bone loss in models of this common oral disease.

Keywords:
Pros1SOCS1/3STAT1/3Tyro3periodontitis

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Area of Science:

  • Oral Biology
  • Immunology
  • Pharmacology

Background:

  • Periodontitis is a prevalent chronic inflammatory disease with significant healthcare costs.
  • TAM receptor tyrosine kinases and their ligands, including Pros1, are crucial for resolving inflammation and are implicated in chronic diseases.

Purpose of the Study:

  • To investigate the therapeutic potential of exogenous Pros1 in periodontitis models.
  • To elucidate the mechanisms underlying Pros1's effects on periodontitis.

Main Methods:

  • Analysis of Pros1 and Tyro3 levels in human gingival specimens.
  • In vitro studies using human gingival epithelial cells stimulated with Porphyromonas gingivalis LPS.
  • In vivo studies in a rat model of periodontitis.
  • Assays included PCR, Western blot, ELISA, and gelatin zymography.

Main Results:

  • Periodontitis patients exhibited higher Pros1 and lower Tyro3 levels in gingival tissues.
  • Exogenous Pros1 inhibited inflammatory cytokine and matrix metalloproteinase production in vitro in a Tyro3-dependent manner.
  • Pros1 treatment reduced gingival inflammation and alveolar bone loss in a rat model.
  • Mechanistic studies identified SOCS1/3 and STAT1/3 as mediators of Pros1's anti-inflammatory effects.

Conclusions:

  • Pros1 demonstrates significant anti-inflammatory and protective effects in both in vitro and in vivo periodontitis models.
  • Pros1 acts through Tyro3, SOCS1/3, and STAT1/3 pathways to mitigate periodontitis.
  • Pros1 represents a potential novel therapeutic agent for periodontitis.