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The Association between Advanced Maternal Age and Macrosomia: A Meta-Analysis
Rui-Xue Dai1, Xiu-Jie He2, Chuan-Lai Hu2,3
11 Department of Acute Infectious Diseases, Disease Control and Prevention Center of Fuyang, Fuyang, Anhui, China.
Childhood Obesity (Print)
|February 8, 2019
Summary
Advanced maternal age (AMA) is a significant risk factor for predicting macrosomia, a condition of excessive fetal growth. This meta-analysis confirms AMA
Area of Science:
- Obstetrics and Gynecology
- Reproductive Health
- Perinatal Medicine
Background:
- Advanced maternal age (AMA), typically defined as maternal age of 35 years or older, is associated with various pregnancy complications.
- Macrosomia, characterized by excessive fetal growth, poses risks to both mother and infant during delivery.
Purpose of the Study:
- To systematically evaluate the association between advanced maternal age and the risk of predicting macrosomia.
- To determine if AMA is a significant independent risk factor for macrosomia through meta-analysis.
Main Methods:
- A systematic review of three databases and reference lists of relevant articles was conducted.
- Meta-analysis of published cohort studies was performed, adjusting for potential confounding factors.
- Random-effects models were used to calculate pooled estimates, with heterogeneity and publication bias assessed.
Main Results:
- Twelve cohort studies met the inclusion criteria for the meta-analysis.
- Advanced maternal age was found to be an important risk factor associated with macrosomia.
- Adjusted odds ratios indicated a significant association: 1.42 (95% CI: 1.25-1.60) for ages 35-39 and 1.40 (95% CI: 1.02-1.78) for ages ≥40, compared to <30 years.
Conclusions:
- Advanced maternal age should be recognized as a crucial risk factor for macrosomia.
- Clinical assessment and monitoring of AMA's effect on macrosomia are essential for optimal pregnancy management.
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